Acquiring new memories in neocortex of hippocampal-lesioned mice.
Acquiring new memories in neocortex of hippocampal-lesioned mice.
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DOI：
10.1038/s41467-022-29208-5
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发表时间：
2022-03-24
影响因子：
16.6
通讯作者：
Guan JS
中科院分区：
文献类型：
--
作者：
Luo W;Yun D;Hu Y;Tian M;Yang J;Xu Y;Tang Y;Zhan Y;Xie H;Guan JS
海马体与新皮质网络相互作用，以恢复和巩固记忆。在这里，我们发现外侧内嗅皮层(LEC)以海马体依赖的方式调制学习诱导的皮质远程伽马同步(20-40 HZ)。长程伽马同步性与theta(7-10 HZ)节律相耦合，并在学习和回忆后增强，它是由LEC的第5层神经元到感觉皮质和联合皮质的第2层神经元的皮质间投射介导的。人工诱导大脑皮层伽马跨皮质区域的同步性改善了海马区受损小鼠的记忆编码，以完成最初的海马区依赖任务。从机制上讲，我们发现大脑皮质c-Fos标记神经元的活动在记忆回忆过程中受到LEC介导的伽马同步性的调节，这意味着皮层同步性在从分散的特征中产生整合的记忆表征方面起到了作用。我们的发现揭示了海马体介导的皮质记忆的组织，并提出了改善认知功能的脑机接口方法。海马区受损的小鼠形成新的记忆。在这里，作者展示了外侧内嗅觉皮质以海马体依赖的方式调制学习诱导的皮质远程伽马同步，并人工诱导皮质区域的伽马同步性改善了海马区受损小鼠的记忆编码。
The hippocampus interacts with the neocortical network for memory retrieval and consolidation. Here, we found the lateral entorhinal cortex (LEC) modulates learning-induced cortical long-range gamma synchrony (20–40 Hz) in a hippocampal-dependent manner. The long-range gamma synchrony, which was coupled to the theta (7–10 Hz) rhythm and enhanced upon learning and recall, was mediated by inter-cortical projections from layer 5 neurons of the LEC to layer 2 neurons of the sensory and association cortices. Artificially induced cortical gamma synchrony across cortical areas improved memory encoding in hippocampal lesioned mice for originally hippocampal-dependent tasks. Mechanistically, we found that activities of cortical c-Fos labeled neurons, which showed egocentric map properties, were modulated by LEC-mediated gamma synchrony during memory recall, implicating a role of cortical synchrony to generate an integrative memory representation from disperse features. Our findings reveal the hippocampal mediated organization of cortical memories and suggest brain-machine interface approaches to improve cognitive function. Hippocampal lesioned mice form new memories. Here, the authors show the lateral entorhinal cortex modulates learning-induced cortical long-range gamma synchrony in a hippocampal-dependent manner and artificially induced cortical gamma synchrony across cortical areas improved memory encoding in hippocampal lesioned mice.
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DOI：
10.1126/science.abf3119
发表时间：
2021-04-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Fernández-Ruiz A;Oliva A;Soula M;Rocha-Almeida F;Nagy GA;Martin-Vazquez G;Buzsáki G
通讯作者：
Buzsáki G
影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
影响因子：
16.2
作者：
Cowansage, Kiriana K.;Shuman, Tristan;Dillingham, Blythe C.;Chang, Allene;Golshani, Peyman;Mayford, Mark
通讯作者：
Mayford, Mark
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
DOI：
10.1073/pnas.0700293104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Armbruster, Blaine N.;Li, Xiang;Roth, Bryan L.
通讯作者：
Roth, Bryan L.