Transcranial ultrasound neuromodulation induces neuronal correlation change in the rat somatosensory cortex.
Transcranial ultrasound neuromodulation induces neuronal correlation change in the rat somatosensory cortex.
复制标题
经颅超声神经调节诱导大鼠体感觉皮层神经元相关性变化。
DOI：
10.1088/1741-2552/ac889f
复制
发表时间：
2022-09-06
影响因子：
4
通讯作者：
He, Bin
中科院分区：
文献类型：
--
作者：
Ramachandran, Sandhya;Niu, Xiaodan;Yu, Kai;He, Bin
经颅聚焦超声（tFUS）是一种神经调节技术，其对于具有高空间特异性的非侵入性脑刺激已成为越来越多关注的焦点。它能够激发和抑制神经回路以及调节感知和行为，但是，我们目前缺乏对tFUS如何调节神经元相互作用的理解。这种理解将有助于阐明tFUS的全身神经调节机制，并允许未来开发神经系统疾病的治疗方法。在这项研究中，我们调查如何tFUS调制神经的相互作用和反应，外周肢体电刺激通过颅内多电极记录在大鼠躯体感觉皮层。我们以脉冲模式提供超声波，以类似于电刺激后发现的方式诱导频率依赖性可塑性。我们发现，在所有频率的超声波刺激后，响应于外周电刺激的神经放电增加，表明TFUS诱导的个体神经元体内兴奋性的变化。我们证明了tFUS声处理重复频率依赖的神经元之间的成对相关性变化，在不同的频率下观察到增加和减少。这些结果扩展了先前的研究，表明tFUS能够诱导突触抑制，并证明其能够调节整个网络动态。
Transcranial focused ultrasound (tFUS) is a neuromodulation technique which has been the focus of increasing interest for noninvasive brain stimulation with high spatial specificity. Its ability to excite and inhibit neural circuits as well as to modulate perception and behavior has been demonstrated, however, we currently lack understanding of how tFUS modulates the ways neurons interact with each other. This understanding would help elucidate tFUS’s mechanism of systemic neuromodulation and allow future development of therapies for neurological disorders. In this study, we investigate how tFUS modulates neural interaction and response to peripheral electrical limb stimulation through intracranial multi-electrode recordings in the rat somatosensory cortex. We deliver ultrasound in a pulsed pattern to induce frequency dependent plasticity in a manner similar to that found following electrical stimulation. We show that neural firing in response to peripheral electrical stimulation is increased after ultrasound stimulation at all frequencies, showing tFUS induced changes in excitability of individual neurons in vivo. We demonstrate tFUS sonication repetition frequency dependent pairwise correlation changes between neurons, with both increases and decreases observed at different frequencies. These results extend previous research showing tFUS to be capable of inducing synaptic depression and demonstrate its ability to modulate network dynamics as a whole.
登录
查看更多内容
DOI：
10.1073/pnas.89.10.4363
发表时间：
1992-05-15
影响因子：
11.1
作者：
DUDEK, SM;BEAR, MF
通讯作者：
BEAR, MF
影响因子：
16.2
作者：
Guo, Hongsun;Hamilton, Mark, II;Lim, Hubert H.
通讯作者：
Lim, Hubert H.
影响因子：
5.6
作者：
Dudek, SM;Fields, RD
通讯作者：
Fields, RD
影响因子：
3.3
作者：
Juan, Eduardo J.;Gonzalez, Rafael;Albors, Gabriel;Ward, Matthew P.;Irazoqui, Pedro
通讯作者：
Irazoqui, Pedro
影响因子：
25
作者：
Boyden, ES;Zhang, F;Deisseroth, K
通讯作者：
Deisseroth, K