Development of a standardized MRI protocol for pancreas assessment in humans.
Development of a standardized MRI protocol for pancreas assessment in humans.
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DOI：
10.1371/journal.pone.0256029
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Powers AC
中科院分区：
文献类型：
--
作者：
Virostko J;Craddock RC;Williams JM;Triolo TM;Hilmes MA;Kang H;Du L;Wright JJ;Kinney M;Maki JH;Medved M;Waibel M;Kay TWH;Thomas HE;Greeley SAW;Steck AK;Moore DJ;Powers AC
磁共振成像（MRI）已检测到1型和2型糖尿病的胰腺体积和其他特征的变化。然而，MRI技术和方法的差异目前限制了胰腺成像纳入多中心试验。本研究的目的是制定一个标准化的胰腺成像MRI协议，并定义这些测量的再现性。在五个地点用不同的MRI硬件和软件对具有已知MRI特性的校准体模进行成像，以制定协调的MRI成像方案。随后，5名健康志愿者使用协调方案在4个部位进行MRI，以评估胰腺大小、形状、表观扩散系数（ADC）、纵向弛豫时间（T1）、磁化传递比（MTR）以及胰腺和肝脏脂肪分数。协调后，胰腺大小，表面积与体积比，扩散，和纵向弛豫时间是可重复的，变异系数小于10%。相比之下，非标准化的图像处理导致MRI测量结果的变化更大。通过使用标准化的MRI图像采集和处理协议，可以将在多个位置进行的胰腺定量MRI纳入临床试验中，比较1型或2型糖尿病患者的胰腺成像测量值和代谢状态。
Magnetic resonance imaging (MRI) has detected changes in pancreas volume and other characteristics in type 1 and type 2 diabetes. However, differences in MRI technology and approaches across locations currently limit the incorporation of pancreas imaging into multisite trials. The purpose of this study was to develop a standardized MRI protocol for pancreas imaging and to define the reproducibility of these measurements. Calibrated phantoms with known MRI properties were imaged at five sites with differing MRI hardware and software to develop a harmonized MRI imaging protocol. Subsequently, five healthy volunteers underwent MRI at four sites using the harmonized protocol to assess pancreas size, shape, apparent diffusion coefficient (ADC), longitudinal relaxation time (T1), magnetization transfer ratio (MTR), and pancreas and hepatic fat fraction. Following harmonization, pancreas size, surface area to volume ratio, diffusion, and longitudinal relaxation time were reproducible, with coefficients of variation less than 10%. In contrast, non-standardized image processing led to greater variation in MRI measurements. By using a standardized MRI image acquisition and processing protocol, quantitative MRI of the pancreas performed at multiple locations can be incorporated into clinical trials comparing pancreas imaging measures and metabolic state in individuals with type 1 or type 2 diabetes.
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