Tumor microenvironment-triggered fabrication of gold nanomachines for tumor-specific photoacoustic imaging and photothermal therapy.
Tumor microenvironment-triggered fabrication of gold nanomachines for tumor-specific photoacoustic imaging and photothermal therapy.
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肿瘤微环境触发金纳米机器的制造用于肿瘤特异性光声成像和光热治疗
DOI：
10.1039/c7sc00700k
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发表时间：
2017-07-01
期刊：
影响因子：
8.4
通讯作者：
Tang B
中科院分区：
文献类型：
--
作者：
Yu Z;Wang M;Pan W;Wang H;Li N;Tang B
基于α-环糊精（α-CD）的金/DNA纳米机器是一种新型的肿瘤选择性诊断和治疗药物。纳米颗粒作为一种新型的癌症治疗药物，近年来得到了广泛的研究。然而，治疗药物的肿瘤选择性和保留性较差，导致诊断和治疗功能的表现不理想。在此，我们开发了一种基于α-环糊精（α-CD）的金/DNA纳米机器，用于肿瘤选择性诊断和治疗。α-CDs位于DNA末端，肿瘤微环境的低pH触发α-CDs的释放，进而导致DNA通过互补碱基配对进行自组装。大尺寸的金聚集体未能从肿瘤组织中逃逸，从而实现了肿瘤特异性靶向和增强滞留的目的。这样，光声信号和光热效应也被激活，从而实现靶向肿瘤的光声成像和光热治疗。体内实验结果表明，所设计的金纳米机器可以作为有效的治疗药物用于诊断和治疗。此外，我们发现α-CD帽具有保护纳米颗粒不被清除和酶消化的能力，这有助于纳米颗粒更有效地到达肿瘤。
An alpha-cyclodextrin (α-CD)-based gold/DNA nanomachine was developed as a novel theranostic agent for tumor-selective diagnosis and therapy. Nanoparticles as novel theranostic agents for cancer treatment have been extensively investigated in recent years. However, the poor tumor selectivity and retention of the theranostic agents result in unsatisfactory performance of both the diagnostic and therapeutic functions. Herein, we developed an alpha-cyclodextrin (α-CD)-based gold/DNA nanomachine for tumor-selective diagnosis and therapy. The α-CDs were capped at the ends of DNA, and their release was triggered by the low pH of the tumor microenvironment, which further resulted in DNA self-assembly through complementary base pairing. The large-sized gold aggregates failed to escape from the tumor tissue, thereby realizing the goal of tumor-specific targeting and enhanced retention. Thus, the photoacoustic signal and photothermal effect are also activated, thereby achieving tumor-targeted photoacoustic imaging and photothermal therapy. In vivo results indicated that the designed gold nanomachines can serve as efficient theranostic agents for diagnosis and therapy. Moreover, we found that the α-CD caps have the ability to protect the nanoparticles from clearance and enzyme digestion, which helps the nanoparticles reach the tumor more efficiently.
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