Caffeine exposure in utero is associated with structural brain alterations and deleterious neurocognitive outcomes in 9-10 year old children.
Caffeine exposure in utero is associated with structural brain alterations and deleterious neurocognitive outcomes in 9-10 year old children.
复制标题
子宫内摄入咖啡因与 9-10 岁儿童的大脑结构改变和有害的神经认知结果有关。
DOI：
10.1016/j.neuropharm.2021.108479
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发表时间：
2021-03-15
影响因子：
4.7
通讯作者：
Foxe JJ
中科院分区：
文献类型：
--
作者：
Christensen ZP;Freedman EG;Foxe JJ
咖啡因是一种非常广泛使用的强效神经调节剂，很容易穿过胎盘屏障，但对妊娠期咖啡因暴露（GCE）对神经发育的长期影响知之甚少。在这里，我们利用从9157名9-10岁儿童的非常大的样本中收集的磁共振成像（MRI）数据，作为青少年大脑和认知发展（ABCD ®）研究的一部分，以研究27个主要纤维束的大脑结构结果作为GCE的函数。通过混合效应二项回归检测GCE和额枕下束和左半球皮质脊髓束（IFOF-LH; CST-LH）的各向异性分数（FA）测量值之间的显著关系。我们进一步研究了这些纤维束，GCE，认知措施（工作记忆，任务效率）和精神病理学措施（外化，内化，躯体化和神经发育）之间的相互作用。GCE与所有精神病理学指标的不良结局相关，但对认知指标的影响可忽略不计。两种纤维束中较高的FA值与神经发育问题的减少和两种认知任务的表现改善相关。我们还发现，在GCE组中，CST-LH中的FA与任务效率之间的相关性降低。这些研究结果表明，GCE可能导致未来的神经发育并发症，这部分是通过改变关键纤维束（如IFOF-LH和CST-LH）的微观结构而发生的。这些数据表明，目前关于限制怀孕期间咖啡因摄入量的指南可能需要重新调整。
Caffeine, a very widely used and potent neuromodulator, easily crosses the placental barrier, but relatively little is known about the long-term impact of gestational caffeine exposure (GCE) on neurodevelopment. Here, we leverage magnetic resonance imaging (MRI) data, collected from a very large sample of 9157 children, aged 9–10 years, as part of the Adolescent Brain and Cognitive Developmentsm (ABCD ®) study, to investigate brain structural outcomes at 27 major fiber tracts as a function of GCE. Significant relationships between GCE and fractional anisotropy (FA) measures in the inferior fronto-occipito fasciculus and corticospinal tract of the left hemisphere (IFOF-LH; CST-LH) were detected via mixed effects binomial regression. We further investigated the interaction between these fiber tracts, GCE, cognitive measures (working memory, task efficiency), and psychopathology measures (externalization, internalization, somatization, and neurodevelopment). GCE was associated with poorer outcomes on all measures of psychopathology but had negligible effect on cognitive measures. Higher FA values in both fiber tracts were associated with decreased neurodevelopmental problems and improved performance on both cognitive tasks. We also identified a decreased association between FA in the CST-LH and task efficiency in the GCE group. These findings suggest that GCE can lead to future neurodevelopmental complications and that this occurs, in part, through alteration of the microstructure of critical fiber tracts such as the IFOF-LH and CST-LH. These data suggest that current guidelines regarding limiting caffeine intake during pregnancy may require some recalibration.
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影响因子：
4.7
作者：
Foxe, John J.;Morie, Kristen P.;Kelly, Simon P.
通讯作者：
Kelly, Simon P.
影响因子：
2.9
作者：
BARR, HM;STREISSGUTH, AP
通讯作者：
STREISSGUTH, AP
影响因子：
3.8
作者：
Bekkhus, M.;Skjothaug, T.;Borge, A. I. H.
通讯作者：
Borge, A. I. H.
影响因子：
4.7
作者：
Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
通讯作者：
ABCD Imaging Acquisition Workgroup
影响因子：
4.7
作者：
Barch DM;Albaugh MD;Avenevoli S;Chang L;Clark DB;Glantz MD;Hudziak JJ;Jernigan TL;Tapert SF;Yurgelun-Todd D;Alia-Klein N;Potter AS;Paulus MP;Prouty D;Zucker RA;Sher KJ
通讯作者：
Sher KJ