Association of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies.
Association of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies.
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DOI：
10.1038/s41598-018-26441-1
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发表时间：
2018-06-05
影响因子：
4.6
通讯作者：
Kivimäki M
中科院分区：
文献类型：
--
作者：
Akbaraly T;Würtz P;Singh-Manoux A;Shipley MJ;Haapakoski R;Lehto M;Desrumaux C;Kähönen M;Lehtimäki T;Mikkilä V;Hingorani A;Humphries SE;Kangas AJ;Soininen P;Raitakari O;Ala-Korpela M;Kivimäki M
饮食可能会改变代谢组学特征，使其更高或更低心血管疾病（CVD）风险。我们的目的是确定与高度遵守饮食建议相关的代谢物谱-替代健康饮食指数（AHEI）-以及与AHEI相关的代谢物在多大程度上也预测了CVD事件。在Whitehall II研究中，使用线性回归模型检查了AHEI评分与80种循环脂质和代谢物（通过核磁共振代谢组学定量）之间的关系（n = 4824，55.9 ± 6.1岁，28.0%女性），并在芬兰青年心血管风险研究中重复（n = 1716，37.7 ± 5.0岁，56.3%女性）。我们使用考克斯模型研究了Whitehall II研究中15.8年随访期间代谢产物与心血管事件之间的关系。在调整混杂因素后，在Whitehall II和Young Finns研究中，较高的AHEI评分（表明更健康的饮食）与较高的脂肪酸（FA）不饱和度和较高的多不饱和FA、omega-3和二十二碳六烯酸相对于总FA的比率相关。在Whitehall II中观察到代谢物与较高AHEI评分和较低CVD风险的相关性一致。坚持健康饮食似乎与降低CVD风险的特定FA相关。
Diet may modify metabolomic profiles towards higher or lower cardiovascular disease (CVD) risk. We aimed to identify metabolite profiles associated with high adherence to dietary recommendations - the Alternative Healthy Eating Index (AHEI) - and the extent to which metabolites associated with AHEI also predict incident CVD. Relations between AHEI score and 80 circulating lipids and metabolites, quantified by nuclear magnetic resonance metabolomics, were examined using linear regression models in the Whitehall II study (n = 4824, 55.9 ± 6.1 years, 28.0% women) and were replicated in the Cardiovascular Risk in Young Finns Study (n = 1716, 37.7 ± 5.0 years, 56.3% women). We used Cox models to study associations between metabolites and incident CVD over the 15.8-year follow-up in the Whitehall II study. After adjustment for confounders, higher AHEI score (indicating healthier diet) was associated with higher degree of unsaturation of fatty acids (FA) and higher ratios of polyunsaturated FA, omega-3 and docosahexaenoic acid relative to total FA in both Whitehall II and Young Finns studies. A concordance of associations of metabolites with higher AHEI score and lower CVD risk was observed in Whitehall II. Adherence to healthy diet seems to be associated with specific FA that reduce risk of CVD.
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影响因子：
5.9
作者：
Akbaraly, Tasnime;Sabia, Severine;Hagger-Johnson, Gareth;Tabak, Adam G.;Shipley, Martin J.;Jokela, Markus;Brunner, Eric J.;Hamer, Mark;Batty, G. David;Singh-Manoux, Archana;Kivimaki, Mika
通讯作者：
Kivimaki, Mika
影响因子：
4.2
作者：
Soininen, Pasi;Kangas, Antti J.;Ala-Korpela, Mika
通讯作者：
Ala-Korpela, Mika
影响因子：
3.4
作者：
Nuotio, Joel;Oikonen, Mervi;Juonala, Markus
通讯作者：
Juonala, Markus
影响因子：
7.7
作者：
Garvey, WT;Kwon, S;Liao, YL
通讯作者：
Liao, YL
影响因子：
7.7
作者：
Raitakari, Olli T.;Juonala, Markus;Viikari, Jorma S. A.
通讯作者：
Viikari, Jorma S. A.