Does overall diet in midlife predict future aging phenotypes? A cohort study.
Does overall diet in midlife predict future aging phenotypes? A cohort study.
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DOI：
10.1016/j.amjmed.2012.10.028
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发表时间：
2013-05
影响因子：
5.9
通讯作者：
Kivimaki, Mika
中科院分区：
文献类型：
--
作者：
Akbaraly, Tasnime;Sabia, Severine;Hagger-Johnson, Gareth;Tabak, Adam G.;Shipley, Martin J.;Jokela, Markus;Brunner, Eric J.;Hamer, Mark;Batty, G. David;Singh-Manoux, Archana;Kivimaki, Mika
关键词：
饮食对特定年龄相关疾病的影响已被广泛研究，但很少有调查采用更全面的方法来确定饮食与老年人整体健康的关系。我们研究了在中年评估的饮食，使用饮食模式和坚持替代健康饮食指数（AHEI），是否与平均16年随访后确定的衰老表型相关。数据来自白厅II队列研究的5350名成人（年龄51.3 ± 5.3岁，29.4%为女性）。在基线（1991-1993年）评估饮食。死亡率、慢性病和功能从医院数据、登记联系和每5年一次的筛查中确定，并用于在随访时产生5个结果：（无慢性病，在身体、心理和认知功能测试中表现良好;非致死性心血管事件（7.3%）、心血管死亡（2.8%）、非心血管死亡（12.7%）和正常衰老（73.2%）。对AHEI的低依从性与心血管和非心血管死亡的风险增加相关。此外，“西式”饮食（特征是大量摄入油炸和甜食、加工食品和红肉、精制谷物和高脂肪乳制品）的参与者理想衰老的几率较低（上三分位数与下三分位数的比值比：0.58; 95%置信区间，0.36-0.94; P = 0.02），与其他健康行为无关。通过将健康老龄化视为心血管、代谢、肌肉骨骼、呼吸、精神和认知功能的复合体，本研究为饮食对衰老表型的影响提供了一个新的视角。
The impact of diet on specific age-related diseases has been studied extensively, but few investigations have adopted a more holistic approach to determine the association of diet with overall health at older ages. We examined whether diet, assessed in midlife, using dietary patterns and adherence to the Alternative Healthy Eating Index (AHEI), is associated with aging phenotypes, identified after a mean 16-year follow-up. Data were drawn from the Whitehall II cohort study of 5350 adults (age 51.3 ± 5.3 years, 29.4% women). Diet was assessed at baseline (1991-1993). Mortality, chronic diseases, and functioning were ascertained from hospital data, register linkage, and screenings every 5 years and were used to create 5 outcomes at follow-up: ideal aging (free of chronic conditions and high performance in physical, mental, and cognitive functioning tests; 4%), nonfatal cardiovascular event (7.3%), cardiovascular death (2.8%), noncardiovascular death (12.7%), and normal aging (73.2%). Low adherence to the AHEI was associated with an increased risk of cardiovascular and noncardiovascular death. In addition, participants with a “Western-type” diet (characterized by high intakes of fried and sweet food, processed food and red meat, refined grains, and high-fat dairy products) had lower odds of ideal aging (odds ratio for top vs bottom tertile: 0.58; 95% confidence interval, 0.36-0.94; P = .02), independently of other health behaviors. By considering healthy aging as a composite of cardiovascular, metabolic, musculoskeletal, respiratory, mental, and cognitive function, the present study offers a new perspective on the impact of diet on aging phenotypes.
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影响因子：
--
作者：
Fung, TT;Willett, WC;Hu, FB
通讯作者：
Hu, FB
影响因子：
7.1
作者：
Lopez-Garcia, E;Schulze, MB;Hu, FB
通讯作者：
Hu, FB
影响因子：
24.3
作者：
Miller, MR;Hankinson, J;Wanger, J
通讯作者：
Wanger, J
影响因子：
158.5
作者：
Trichopoulou, A;Costacou, T;Trichopoulos, D
通讯作者：
Trichopoulos, D
DOI：
10.1136/bmj.a1344
发表时间：
2008-09-11
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Sofi F;Cesari F;Abbate R;Gensini GF;Casini A
通讯作者：
Casini A