Comparison of assembled Clostridium botulinum A1 genomes revealed their evolutionary relationship.
Comparison of assembled Clostridium botulinum A1 genomes revealed their evolutionary relationship.
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DOI：
10.1016/j.ygeno.2013.12.003
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发表时间：
2014-01
期刊：
影响因子：
4.4
通讯作者：
Lin, Wei-Jen
中科院分区：
文献类型：
--
作者：
Ng, Virginia;Lin, Wei-Jen
肉毒梭菌包括产生肉毒神经毒素（BoNT/A-G）的七种血清型中的至少一种的细菌。四个密切相关的A1或A1（B）型菌株的基因组序列的可用性，以及A1特异性微阵列，允许分析它们的基因组组织和进化关系。四个基因组共享>90%的核心基因和>96%的功能组。基于COG的系统发育分析显示，A1（B）株NCTC 2916与B1和F1的亲缘关系较A1株近。三种A1菌株的基因组比对显示出高度相似的染色体结构，ATCC 19397的基因组中有三个小缺口，Hall A的基因组中有一个额外的缺口，表明ATCC 19379是Hall A和ATCC 3502之间的进化中间体。四个缺口区域的分析表明潜在的水平基因转移和重组事件的A1菌株的进化重要。
Clostridium botulinum encompasses bacteria that produce at least one of the seven serotypes of botulinum neurotoxin (BoNT/A-G). The availability of genome sequences of four closely related Type A1 or A1(B) strains, as well as the A1-specific microarray, allowed the analysis of their genomic organizations and evolutionary relationship. The four genomes share >90% core genes and >96% functional groups. Phylogenetic analysis based on COG shows closer relations of the A1(B) strain, NCTC 2916, to B1 and F1 than A1 strains. Alignment of the genomes of the three A1 strains revealed a highly similar chromosomal structure with three small gaps in the genome of ATCC 19397 and one additional gap in the genome of Hall A, suggesting ATCC 19379 as an evolutionary intermediate between Hall A and ATCC 3502. Analyses of the four gap regions indicated potential horizontal gene transfer and recombination events important for the evolution of A1 strains.
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影响因子：
2.6
作者：
Jovita, MR;Collins, MD;East, AK
通讯作者：
East, AK
影响因子：
2.6
作者：
Dineen, SS;Bradshaw, M;Johnson, EA
通讯作者：
Johnson, EA
DOI：
10.1016/j.bbrc.2007.06.166
发表时间：
2007-09-14
影响因子：
3.1
作者：
Marshall, Kristin M.;Bradshaw, Marite;Johnson, Eric A.
通讯作者：
Johnson, Eric A.
影响因子：
2
作者：
Anderson, N. M.;Larkin, J. W.;Hall, P. A.
通讯作者：
Hall, P. A.
影响因子：
4.4
作者：
Franciosa, G;Floridi, F;Aureli, P
通讯作者：
Aureli, P