Is impaired response inhibition independent of symptom dimensions in obsessive-compulsive disorder? Evidence from ERPs.
Is impaired response inhibition independent of symptom dimensions in obsessive-compulsive disorder? Evidence from ERPs.
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强迫症中反应抑制受损是否与症状维度无关？
DOI：
10.1038/srep10413
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发表时间：
2015-05-20
影响因子：
4.6
通讯作者：
Zhong M
中科院分区：
文献类型：
--
作者：
Lei H;Zhu X;Fan J;Dong J;Zhou C;Zhang X;Zhong M
Impaired response inhibition has been consistently reported in patients diagnosed with obsessive-compulsive disorder (OCD). This clinically heterogeneous disorder is characterized by several symptom dimensions that may have distinct, but partially overlapping, neural correlates. The present study examined whether alterations in response inhibition may be related to symptom severity and symptom dimensions. Event-related potentials (ERPs) were recorded in a group of 42 medication-free OCD patients as well as 42 healthy controls during a stop-signal task. Symptom dimension scores were obtained using the Yale-Brown Obsessive Compulsive Scale symptom checklist. OCD patients showed longer stop-signal reaction times (SSRT,p< 0.01) and larger stop-N2 amplitudes (p< 0.01) compared to healthy controls. Neither the longer SSRT nor the larger stop-N2 scores were significantly correlated with symptom severity or present or lifetime OCD symptoms in OCD patients. These results indicate that deficient response inhibition is a common occurrence in OCD patients that is independent of global symptom severity and symptom dimensions. These data support the notion that impaired response inhibition may be a general attribute of patients with OCD.
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影响因子：
3.6
作者：
Foa, EB;Huppert, JD;Salkovskis, PM
通讯作者：
Salkovskis, PM
影响因子：
2.1
作者：
Dittrich, Winand H.;Johansen, Thomas;Kischka, Udo
通讯作者：
Kischka, Udo
影响因子：
1.3
作者：
Falkenstein, M;Hoormann, J;Hohnsbein, J
通讯作者：
Hohnsbein, J
强迫症：对DSM-V的诊断标准以及可能的亚型和尺寸指数的回顾。
影响因子：
7.4
作者：
Leckman, James E.;Denys, Damiaan;Simpson, H. Blair;Mataix-Cols, David;Hollander, Eric;Saxena, Sanjaya;Miguel, Euripedes C.;Rauch, Scott L.;Goodman, Wayne K.;Phillips, Katharine A.;Stein, Dan J.
通讯作者：
Stein, Dan J.
影响因子：
11.3
作者：
Hasler, G;LaSalle-Ricci, VH;Murphy, DL
通讯作者：
Murphy, DL