Functions and emerging applications of bacteriocins.
Functions and emerging applications of bacteriocins.
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DOI：
10.1016/j.copbio.2017.07.011
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发表时间：
2018-03
影响因子：
7.7
通讯作者：
Dicks LM
中科院分区：
文献类型：
--
作者：
Chikindas ML;Weeks R;Drider D;Chistyakov VA;Dicks LM
细菌素是核糖体合成的抗菌肽，传统上被用作食品防腐剂，在发酵过程中添加或由发酵剂产生。对少数几种细菌素的深入研究开辟了新的研究领域，拓宽了这些抗菌肽的应用。随着遗传学和纳米技术的快速发展，将细菌素开发成下一代抗生素的可能性，为更迷人的应用铺平了道路，例如新型载体分子（递送系统）和癌症治疗。此外，一些细菌素被发现调节群体感应，这表明这组物质的新应用。虽然对来自革兰氏阴性菌的细菌素有一些有趣的转化研究，但大多数面向应用的研究都集中在来自革兰氏阳性微生物（主要是乳酸菌）的细菌素上。细菌素的应用正从食品领域扩展到人类健康领域。
Bacteriocins, defined as ribosomally synthesized antimicrobial peptides, have traditionally been used as food preservatives, either added or produced by starter cultures during fermentation. In-depth studies of a select few bacteriocins opened exiting new research fields and broadened the application of these antimicrobial peptides. The possibility of developing bacteriocins into next generation antibiotics, accompanied with the rapid development in genetics and nanotechnology, paves the way to even more fascinating applications such as novel carrier molecules (delivery systems) and the treatment of cancer. Also, some bacteriocins are found to regulate quorum sensing which suggests novel applications for this group of substances. While there is some interesting translational research on bacteriocins from Gramnegative bacteria, the majority of application-oriented studies are focused on bacteriocins from Grampositive microorganisms, mostly lactic acid bacteria. The applications of bacteriocins are expanding from food to human health.
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影响因子：
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