Associations between serum copper, zinc, selenium level and sex hormones among 6-19 years old children and adolescents in NHANES 2013-2016.
Associations between serum copper, zinc, selenium level and sex hormones among 6-19 years old children and adolescents in NHANES 2013-2016.
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DOI：
10.3389/fendo.2022.924338
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发表时间：
2022
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
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铜、锌、硒是人体必需的微量元素，对性激素有重要影响。关于这三种微量元素与性激素之间关系的研究很少。因此，本研究旨在利用2013-2016年全国健康与营养调查(NHANES)的数据，对6-19岁的受试者血清铜、锌、硒与睾酮、雌二醇、SHBG的关系进行研究。1097名参与者被登记，并被分成男性/女性儿童和青少年。采用加权线性回归模型和回归诊断相结合的方法，按不同层次估计微量元素与性激素的关系。我们的结果表明，铜与睾酮和雌二醇呈负相关，而与SHBG呈正相关。在男性青少年和女性儿童中，锌与睾酮呈正相关，而在女性青少年中，锌与睾酮呈负相关。此外，锌与SHBG呈负相关。随着硒水平的升高，睾酮和雌二醇水平升高，SHBG下降。总体而言，本研究使用了更标准化的统计方法来研究铜、锌、硒与睾酮、雌二醇、SHBG的关系。进一步的研究应注意统计方法上的一些细节。
Copper, zinc, and selenium are essential trace elements for human and have important effects on sex hormones. There are few studies on the relationships between the three trace elements and sex hormones. Therefore, our study aimed to investigate the relationships between serum copper, zinc, selenium and testosterone, estradiol, SHBG using data from the National Health and Nutrition Examination Survey (NHANES) 2013-2016 in participants 6-19 years. 1097 participants were enrolled and stratified into male/female children and adolescents. Weighted linear regression models combined regression diagnosis were used to estimate the relationships between trace elements and sex hormones according to the different stratifications. Our results showed that copper was inversely associated with testosterone and estradiol but positively correlated with SHBG. Zinc had positive relationships with testosterone in male adolescents and female children but an inverse relationship with testosterone in female adolescents. Furthermore, a negative association was observed between zinc and SHBG. With the rise of selenium level, testosterone and estradiol were increased but SHBG was decreased. In general, this study used more standardized statistical methods to investigate the relationships between copper, zinc, selenium and testosterone, estradiol, SHBG. Further study should pay attention to some details in statistical methods.
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影响因子：
2.9
作者：
Liu YL;Zhang MN;Tong GY;Sun SY;Zhu YH;Cao Y;Zhang J;Huang H;Niu B;Li H;Guo QH;Gao Y;Zhu DL;Li XY;Hypogonadotropic Hypogonadism Intervention Study (HHIS) Group
通讯作者：
Hypogonadotropic Hypogonadism Intervention Study (HHIS) Group
DOI：
10.1016/j.jtemb.2017.09.001
发表时间：
2017-01-01
影响因子：
3.5
作者：
Erkekoglu, Pinar;Durmaz, Erdem;Kocer-Gumusel, Belma
通讯作者：
Kocer-Gumusel, Belma
影响因子：
168.9
作者：
Jasienska, Grazyna;Bribiescas, Richard G.;Nunez-de la Mora, Alejandra
通讯作者：
Nunez-de la Mora, Alejandra
影响因子：
7.2
作者：
Austin, Peter C.;Steyerberg, Ewout W.
通讯作者：
Steyerberg, Ewout W.
影响因子：
8.9
作者：
Bai, Rongpan;Huang, Yun;Guo, Jing
通讯作者：
Guo, Jing