Nanoplasmonics Enabling Cancer Diagnostics and Therapy.
Nanoplasmonics Enabling Cancer Diagnostics and Therapy.
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作者：
在早期癌症检测和治疗方面的最新进展，导致了这种疾病的检测和治疗方式的范式转变。特别是，治疗已经变得更加有针对性和局部化，以尽量减少传统治疗方法（如化疗）中常见的全身副作用。在这场革命的前沿是等离子体金纳米粒子的利用，它作为一种高效的纳米平台，从药物输送到等离子体增强治疗（如光热治疗），已经受到越来越多的关注。在本文中，我们重点介绍了我们实验室通过整合等离子体、光子学和纳米技术在癌症诊断和治疗方面取得的几项进展。我们讨论了等离子体活性金纳米粒子（GNS）的发展和应用，GNS是一种具有许多分支的独特形状的纳米粒子，可以极大地放大共振波长下的热产生。GNS还成功地应用于肿瘤成像环境，从双光子荧光到表面增强拉曼散射（SERS）传感和成像。最后，GNS已与免疫治疗应用相结合，作为免疫检查点抑制剂的有效辅助。这种GNS和免疫疗法的结合，即所谓的协同免疫光纳米疗法（SYMPHONY），已被证明在控制长期癌症免疫和转移性肿瘤方面是有效的。
Recent advances in the state of the art for early cancer detection and therapy have led to a paradigm shift in the way the disease is detected and treated. In particular, treatments have become much more targeted and localized to minimize systemic body-wide side effects common in traditional treatment methods such as chemotherapy. At the forefront of this revolution is the utilization of plasmonic gold nanoparticles, which have gained increasing attention as a highly effective nanoplatform ranging from drug delivery to plasmonics-enhanced treatments such as photothermal therapy. In this paper, we highlight several advances our laboratory has developed in the pursuit of cancer diagnostics and therapeutics by integrating plasmonics, photonics, and nanotechnology. We discuss the development and applications of plasmonics-active gold nanostar (GNS), a uniquely shaped nanoparticle with numerous branches that serve to greatly amplify the thermal generation at resonant wavelengths. GNS has also been successfully used in tumor imaging contexts from two-photon fluorescence to surface-enhanced Raman scattering (SERS) sensing and imaging. Finally, GNS has been coupled with immunotherapy applications to serve as an effective adjuvant to immune checkpoint inhibitors. This combination of GNS and immunotherapy, the so called synergistic immuno photo nanotherapy (SYMPHONY), has been shown to be effective at controlling long-lasting cancer immunity and metastatic tumors.
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DOI：
10.1016/j.jphotobiol.2020.112110
发表时间：
2021-04-14
影响因子：
5.4
作者：
Fernandes, Donald A.;Fernandes, Dennis D.;Kolios, Michael C.
通讯作者：
Kolios, Michael C.
DOI：
10.1021/la202602q
发表时间：
2011-10-04
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
Fales AM;Yuan H;Vo-Dinh T
通讯作者：
Vo-Dinh T
影响因子：
3.1
作者：
Frey, Benjamin;Weiss, Eva-Maria;Gaipl, Udo S.
通讯作者：
Gaipl, Udo S.
影响因子：
10.8
作者：
Jain, Prashant K.;El-Sayed, Mostafa A.
通讯作者：
El-Sayed, Mostafa A.
影响因子：
3.9
作者：
Fernandes DA;Appak-Baskoy S;Berndl E;Kolios MC
通讯作者：
Kolios MC