Cardiac function in mild and severe primary hypothyroidism.

Cardiac function in mild and severe primary hypothyroidism.
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轻度和重度原发性甲状腺功能减退症的心脏功能。

DOI:
10.1016/0024-3205(82)90281-8
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发表时间:
1982
期刊:
影响因子:
6.1
通讯作者:
Maloof,F
Maloof,F
中科院分区:
医学2区
文献类型:
--
作者:
Ridgway,EC;Ladenson,PW;Cooper,DS;Daniels,GH;Francis,GS;Maloof,F

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采用无创技术分析了100例轻度至重度原发性甲状腺功能减退症患者的左心室功能异常。这些研究揭示了心脏功能的显着异常,与血清T4水平呈负相关。通过甲状腺激素治疗,心脏功能异常是完全可逆的。即使在轻度亚临床甲状腺功能减退症患者中,通过使TSH分泌正常化的甲状腺激素剂量,也可实现左心室功能的显著改变。用L-T4或L-T3治疗可导致正常的心脏功能,尽管L-T3在低于使TSH分泌正常化所需的剂量下可产生正常的心脏功能。这些研究旨在为甲状腺功能减退症的最佳治疗提供新的信息。
One hundred patients with mild to severe primary hypothyroidism have been analyzed for abnormalities in left ventricular performance utilizing noninvasive techniques. These studies have revealed significant abnormalities in cardiac function which correlated inversely with serum T4levels. The abnormalities in cardiac function were completely reversible with thyroid hormone therapy. Even in patients with mild subclinical hypothyroidism, significant changes in left ventricular performance were achieved by doses of thyroid hormone which normalized TSH secretion. Therapy with either L-T4or L-T3resulted in normal cardiac function though L-T3produced normal cardiac function on lower doses than were necessary to normalize TSH secretion. These studies are intended to provide new information on the optimal treatment of hypothyroidism.
通过对动脉音进行定时,改善甲状腺功能亢进症和甲状腺功能减退症的诊断和治疗。
DOI: 10.1210/jcem-42-2-330
发表时间: 1976
期刊: The Journal of clinical endocrinology and metabolism
影响因子: --
作者:
R. Young;A. V. Van Herle;D. Rodbard
通讯作者: D. Rodbard
DOI: 10.1172/jci103906
发表时间: 1959-01-01
影响因子: 15.9
作者:
GRAETTINGER, JS;MUENSTER, JJ;CAMPBELL, JA
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DOI: 10.1172/jci105658
发表时间: 1967
期刊: The Journal of clinical investigation
影响因子: --
作者:
R. Buccino;J. Spann;P. Pool;E. Sonnenblick;E. Braunwald
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通过对动脉音进行计时来估计甲状腺功能。
DOI: 10.1001/jama.1967.03130110110038
发表时间: 1967
期刊: JAMA
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促甲状腺激素释放激素并不是哺乳期间催乳素释放的唯一生理介质。
DOI: 10.1056/nejm197405232902103
发表时间: 1974
期刊: The New England journal of medicine
影响因子: --
作者:
Kaare M. Gautvik;A. H. Tashjian;I. Kourides;B. Weintraub;C. Graeber;Farahe Maloof;K. Suzuki;James E. Zuckerman
通讯作者: James E. Zuckerman