Obesity and risk of colorectal cancer: a systematic review of prospective studies.
Obesity and risk of colorectal cancer: a systematic review of prospective studies.
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DOI：
10.1371/journal.pone.0053916
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Qin H
中科院分区：
文献类型：
--
作者：
Ma Y;Yang Y;Wang F;Zhang P;Shi C;Zou Y;Qin H
越来越多的证据表明，肥胖可能与结直肠癌（CRC）的风险有关。使用荟萃分析对评估肥胖与CRC风险相关性的前瞻性研究进行系统评价。在2012年1月之前，通过检索MEDLINE和EMBASE数据库确定相关研究，无限制。我们还审查了检索文章的参考文献列表。我们纳入了前瞻性研究，这些研究报告了全身性肥胖[使用体重指数（BMI）测量]或中心性肥胖[使用腰围（WC）测量]与结直肠癌、结肠癌或直肠癌风险之间相关性的相对风险（RR）估计值和95%置信区间（CI）。来自几个国家的大约9，000，000名参与者被包括在这项分析中。41项关于全身性肥胖的研究和13项关于中心性肥胖的研究被纳入荟萃分析。肥胖与正常BMI类别的CRC合并RR为1.334（95% CI，1.253-1.420），最高与最低WC类别的CRC合并RR为1.455（95% CI，1.327-1.596）。BMI研究间存在异质性（P<0.001），WC研究间无异质性（P = 0.323）。 在这项荟萃分析中，全身性肥胖和中心性肥胖均与结直肠癌的风险呈正相关。
Mounting evidence indicates that obesity may be associated with the risk of colorectal cancer (CRC). To conduct a systematic review of prospective studies assessing the association of obesity with the risk of CRC using meta-analysis. Relevant studies were identified by a search of MEDLINE and EMBASE databases before January 2012, with no restrictions. We also reviewed reference lists from retrieved articles. We included prospective studies that reported relative risk (RR) estimates with 95% confidence intervals (CIs) for the association between general obesity [measured using body mass index (BMI)] or central obesity [measured using waist circumference (WC)] and the risk of colorectal, colon, or rectal cancer. Approximately 9, 000, 000 participants from several countries were included in this analysis. 41 studies on general obesity and 13 studies on central obesity were included in the meta-analysis. The pooled RRs of CRC for the obese vs. normal category of BMI were 1.334 (95% CI, 1.253–1.420), and the highest vs. lowest category of WC were 1.455 (95% CI, 1.327–1.596). There was heterogeneity among studies of BMI (P<0.001) but not among studies of WC (P = 0.323). Both of general and central obesity were positively associated with the risk of CRC in this meta-analysis.
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影响因子：
3.8
作者：
Levi, Zohar;Kark, Jeremy D.;Shamiss, Ari
通讯作者：
Shamiss, Ari
影响因子：
5
作者：
Bowers, Katherine;Albanes, Demetrius;Stolzenberg-Solomon, Rachael
通讯作者：
Stolzenberg-Solomon, Rachael
影响因子：
2.3
作者：
Lin, J;Zhang, SM;Buring, JE
通讯作者：
Buring, JE
影响因子：
3.8
作者：
Bassett, Julie K.;Severi, Gianluca;Giles, Graham G.
通讯作者：
Giles, Graham G.
影响因子：
4.3
作者：
Dai, Zhe;Xu, Yan-Cheng;Niu, Li
通讯作者：
Niu, Li