Metabolic syndrome and inflammatory responses to long-term particulate air pollutants.
Metabolic syndrome and inflammatory responses to long-term particulate air pollutants.
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代谢综合征和对长期颗粒空气污染物的炎症反应。
DOI：
10.1289/ehp.10565
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发表时间：
2008-05
影响因子：
10.4
通讯作者：
Schwartz, Joel
中科院分区：
文献类型：
--
作者：
Chen, Jiu-Chiuan;Schwartz, Joel
关键词：
目前仍然缺乏将炎症与长期颗粒物（PM）暴露联系起来的人类数据。新出现的证据表明，代谢综合征（MS）患者可能是一个更易感的人群。我们的目标是检查与长期PM暴露和MS依赖性易感性相关的潜在炎症反应。我们对来自第三次全国健康和营养检查调查的白色血细胞（WBC）计数和MS数据以及来自美国环境保护局空气动力学信息检索系统的PM10（空气动力学直径< 10 μm的PM）数据进行了二次分析。估计1年的PM10暴露量汇总在每个居民普查块组的质心，使用距离加权平均值从所有监测器在居住和毗邻县。我们的分析仅限于WBC正常（4，000 - 11，000 × 106/L）、无心血管疾病、完整的PM10和MS数据、现居地居住时间> 1年的成人（20-89岁）（n = 2，978;年龄48.5 ± 17.8岁）。构建混合效应模型以解释自相关性和潜在混杂因素。在调整人口统计学、社会经济因素、生活方式、居住特征和MS后，我们观察到WBC计数和估计的当地PM10水平之间存在统计学显著相关性（p = 0.035）。来自污染最轻地区的参与者（1年PM10 <第一四分位数临界值：27.8 μg/m3）的WBC计数低于其他地区（差异= 145 × 106/L; 95%置信区间，10-281）。我们还注意到，在MS组分增加的亚群中，PM10和WBC之间存在分级相关性，无MS患者的WBC差异为91 × 106/L，而有3、4和5项代谢异常的患者的WBC差异为214、338和461 × 106/L（趋势检验p = 0.15）。我们的研究揭示了长期PM暴露与炎症的血液学标志物之间的正相关性，并支持假设的MS依赖性易感性。
Human data linking inflammation with long-term particulate matter (PM) exposure are still lacking. Emerging evidence suggests that people with metabolic syndrome (MS) may be a more susceptible population. Our goal was to examine potential inflammatory responses associated with long-term PM exposure and MS-dependent susceptibility. We conducted secondary analyses of white blood cell (WBC) count and MS data from The Third National Health and Nutrition Examination Survey and PM10 (PM with aerodynamic diameter < 10 μm) data from the U.S. Environmental Protection Agency Aerometric Information Retrieval System. Estimated 1-year PM10 exposures were aggregated at the centroid of each residential census-block group, using distance-weighted averages from all monitors in the residing and adjoining counties. We restricted our analyses to adults (20–89 years of age) with normal WBC (4,000–11,000 × 106/L), no existing cardiovascular disease, complete PM10 and MS data, and living in current residences > 1 year (n = 2,978; age 48.5 ± 17.8 years). Mixed-effects models were constructed to account for autocorrelation and potential confounders. After adjustment for demographics, socioeconomic factors, lifestyles, residential characteristics, and MS, we observed a statistically significant association between WBC count and estimated local PM10 levels (p = 0.035). Participants from the least polluted areas (1-year PM10 < 1st quartile cutoff: 27.8 μg/m3) had lower WBC counts than the others (difference = 145 × 106/L; 95% confidence interval, 10–281). We also noted a graded association between PM10 and WBC across subpopulations with increasing MS components, with 91 × 106/L difference in WBC for those with no MS versus 214, 338, and 461 × 106/L for those with 3, 4, and 5 metabolic abnormalities (trend-test p = 0.15). Our study revealed a positive association between long-term PM exposure and hematological markers of inflammation and supported the hypothesized MS-dependent susceptibility.
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影响因子：
10.4
作者：
Dockery DW;Luttmann-Gibson H;Rich DQ;Link MS;Mittleman MA;Gold DR;Koutrakis P;Schwartz JD;Verrier RL
通讯作者：
Verrier RL
影响因子：
5.4
作者：
Holguin, F;Téllez-Rojo, MM;Romieu, I
通讯作者：
Romieu, I
影响因子：
37.8
作者：
O'Neill, MS;Veves, A;Schwartz, J
通讯作者：
Schwartz, J
影响因子：
37.8
作者：
Pearson, TA;Mensah, GA;Vinicor, F
通讯作者：
Vinicor, F
DOI：
10.1038/sj.jea.7500408
发表时间：
2005-07-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Liao, DP;Heiss, G;Salomaa, V
通讯作者：
Salomaa, V