Effect of iron liposomes on anemia of inflammation.
Effect of iron liposomes on anemia of inflammation.
复制标题
铁脂质体对炎症性贫血的影响。
DOI：
10.1016/j.ijpharm.2013.06.078
复制
发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Chang Y
中科院分区：
文献类型：
--
作者：
Yuan L;Geng L;Ge L;Yu P;Duan X;Chen J;Chang Y
补充铁强化食品是治疗缺铁性疾病的有效方法。然而，用于治疗炎症性贫血（AI）的传统铁剂效果甚微。本研究采用旋转蒸发薄膜超声法制备了血红素脂质体（HEME-LIP）和柠檬酸铁脂质体（FAC-LIP），并对其包封率、微观结构、粒径分布和zeta电位进行了研究。两种类型的铁脂质体显示稳定的物理特性。治疗AI大鼠模型时，FAC-LIP和HEME-LIP分别比柠檬酸铁（FAC）和血红素提高血清铁水平119%和54%。此外，铁调素，铁稳态的一个关键调节剂是上调这些铁脂质体，特别是HEME-LIP。这些结果表明铁脂质体的吸收比未包封的铁试剂的吸收改善。因此，铁脂质体可用于强化食物以治疗缺铁性疾病，特别是AI。
Supplementation with iron-fortified foods is an effective method for treating iron deficiency diseases. However, traditional iron agents used to treat anemia of inflammation (AI) have little effect. In this study, two types of iron liposomes, heme liposomes (HEME-LIP) and ferric citrate liposomes (FAC-LIP), were prepared by the rotary-evaporated film-ultrasonication method, and the encapsulation efficiencies, microstructures, size distributions and zeta potentials were assessed. Both types of iron liposomes showed stable physical characteristics. When used to treat rat models of AI, FAC-LIP and HEME-LIP could increase serum iron levels by 119% and 54% higher than did ferric citrate (FAC) and heme, respectively. Furthermore, the hepcidin, a key regulator of iron homeostasis was up-regulated by these iron liposomes, especially by HEME-LIP. These results indicate that the absorption of iron liposomes was improved over that of unencapsulated iron agents. Thus, iron liposomes may be used to fortify food in treating iron deficiency diseases, especially AI.
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影响因子：
2.4
作者：
Nemeth, Elizabeta;Ganz, Tomas
通讯作者：
Ganz, Tomas
影响因子：
6.4
作者：
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后生动物中血红素和卟啉的贩运
DOI：
10.1002/chin.201006263
发表时间：
2010
期刊：
ChemInform
影响因子：
--
作者：
S. Severance;I. Hamza
通讯作者：
I. Hamza
影响因子：
--
作者：
Dong A;Sunkara M;Panchatcharam M;Salous A;Selim S;Morris AJ;Smyth SS
通讯作者：
Smyth SS
影响因子：
4
作者：
Kong, Wei-Na;Zhao, Shu-E;Chang, Yan-Zhong
通讯作者：
Chang, Yan-Zhong