Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections.
Fetal exposure to ethanol has long-term effects on the severity of influenza virus infections.
复制标题
DOI：
10.4049/jimmunol.0803881
复制
发表时间：
2009-06-15
期刊：
影响因子：
--
通讯作者：
Legge KL
中科院分区：
文献类型：
--
作者：
McGill J;Meyerholz DK;Edsen-Moore M;Young B;Coleman RA;Schlueter AJ;Waldschmidt TJ;Cook RT;Legge KL
孕妇饮酒是一个重大的公共卫生问题，尽管对胎儿的风险众所周知，包括身体和智力发育迟缓和畸形。虽然临床研究有限，但它们表明，在宫内接触酒精也会导致幼稚新生儿明显的免疫缺陷。然而，人们对胎儿酒精暴露(FAE)对成人感染的影响知之甚少。因此，为了确定FAE对疾病易感性和成人免疫系统的长期影响，我们用流感病毒感染FAE成年小鼠。在这里，我们证明了在怀孕和哺乳期间暴露于酒精的小鼠表现出疾病严重程度的增加，以及流感病毒感染后肺病毒滴度的增加和持续。成年后二次接触酒精会进一步加剧这些影响。此外，我们证明FAE小鼠已经损害了适应性免疫反应，包括病毒特异性肺CD8T细胞的数量减少，肺B细胞病灶的大小和频率减少，以及流感感染后流感特异性抗体的产生减少。综上所述，我们的结果表明，FAE会导致免疫和对流感病毒感染的易感性出现显著和长期的缺陷，FAE个体患严重和致命呼吸道感染的风险可能会增加。
Alcohol use by pregnant women is a significant public health issue despite well-described risks to the fetus including physical and intellectual growth retardation and malformations. While clinical studies are limited, they suggest that in utero alcohol exposure also results in significant immune deficiencies in naïve neonates. However, little is known about fetal alcohol exposure (FAE) effects on adult infections. Therefore, to determine the long-term effects of FAE on disease susceptibility and the adult immune system, we infected FAE adult mice with influenza virus. Herein, we demonstrate that mice exposed to ethanol during gestation and nursing exhibit enhanced disease severity as well as increased and sustained pulmonary viral titers following influenza virus infection. Secondary exposure to alcohol as an adult further exacerbates these effects. Moreover, we demonstrate that FAE mice have impaired adaptive immune responses, including decreased numbers of virus-specific pulmonary CD8 T cells, a decreased size and frequency of pulmonary B cell foci, and reduced production of influenza-specific antibody following influenza infection. Together, our results suggest that FAE induces significant and long-term defects in immunity and susceptibility to influenza virus infection and that FAE individuals could be at increased risk for severe and fatal respiratory infections.
登录
查看更多内容
DOI：
10.1111/j.1530-0277.1998.tb03665.x
发表时间：
1998-04-01
影响因子：
3.2
作者：
Jerrells, TR;Weinberg, J
通讯作者：
Weinberg, J
影响因子：
4.4
作者：
Meyerholz, David K.;Edsen-Moore, Michelle;Legge, Kevin L.
通讯作者：
Legge, Kevin L.
DOI：
10.1097/01.alc.0000167956.28160.5e
发表时间：
2005-06-01
影响因子：
3.2
作者：
Gauthier, TW;Drews-Botsch, C;Brown, LAS
通讯作者：
Brown, LAS
DOI：
10.1111/j.1530-0277.1998.tb03969.x
发表时间：
1998-11-01
影响因子：
3.2
作者：
Biber, KL;Moscatello, KM;Wolcott, RM
通讯作者：
Wolcott, RM
DOI：
10.1111/j.1530-0277.1989.tb00362.x
发表时间：
1989-08-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
EWALD, SJ
通讯作者：
EWALD, SJ