Redistribution of tissue zinc pools during lactation and dyshomeostasis during marginal zinc deficiency in mice.
Redistribution of tissue zinc pools during lactation and dyshomeostasis during marginal zinc deficiency in mice.
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DOI：
10.1016/j.jtemb.2014.06.002
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Kelleher SL
中科院分区：
文献类型：
--
作者：
McCormick NH;King J;Krebs N;Soybel DI;Kelleher SL
锌（Zn）的需求量在哺乳期增加。增加的需求部分通过增加饮食中锌的吸收来满足。据估计，60%至80%的育龄妇女由于生物可利用锌的摄入量低以及怀孕和哺乳期间需求量增加而面临锌缺乏症的风险。锌如何在体内重新分配以满足哺乳的需求，以及锌缺乏如何影响这一过程，目前尚不清楚。雌性C57 BL/6 J小鼠饲喂对照（ZA; 30 mg Zn/kg）或轻度缺锌（ZD; 15 mg Zn/kg）饮食30天，然后交配至泌乳中期，并与饲喂相同饮食的未经产小鼠进行比较。虽然胃和血浆锌浓度增加，在哺乳期喂养ZA的小鼠，喂养ZD的小鼠有较低的胃锌浓度和废除血浆锌水平在哺乳期。此外，股骨锌减少哺乳期喂养ZA的小鼠，而喂养ZD的小鼠没有经历这种减少。此外，红细胞，胰腺，肌肉和乳腺锌浓度增加，肝脏和肾上腺锌下降，在哺乳期，独立的饮食，而肾脏锌浓度增加，只有在小鼠喂养ZD。最后，母亲锌缺乏显着增加肝脏锌浓度的后代，但降低体重增加和生存。这项研究提供了新的见解锌是如何重新分配，以满足增加的代谢需求的哺乳期和边际锌缺乏如何干扰这些稳态的调整。
Zinc (Zn) requirements are increased during lactation. Increased demand is partially met through increased Zn absorption from the diet. It is estimated that 60 to 80% of women of reproductive age are at risk for Zn deficiency due to low intake of bioavailable Zn and increased demands during pregnancy and lactation. How Zn is redistributed within the body to meet the demands of lactation, and how Zn deficiency affects this process, is not understood. Female C57bl/6J mice were fed a control (ZA; 30 mg Zn/kg) or a marginally Zn deficient (ZD; 15 mg Zn/kg) diet for 30 d prior to mating through mid-lactation and compared with nulliparous mice fed the same diets. While stomach and plasma Zn concentration increased during lactation in mice fed ZA, mice fed ZD had lower stomach Zn concentration and abrogated plasma Zn levels during lactation. Additionally, femur Zn decreased during lactation in mice fed ZA, while mice fed ZD did not experience this decrease. Furthermore, red blood cell, pancreas, muscle and mammary gland Zn concentration increased, and liver and adrenal gland Zn decreased during lactation, independent of diet, while kidney Zn concentration increased only in mice fed ZD. Finally, maternal Zn deficiency significantly increased the liver Zn concentration in offspring but decreased weight gain and survival. This study provides novel insight into how Zn is redistributed to meet the increased metabolic demands of lactation and how marginal Zn deficiency interferes with these homeostatic adjustments.
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影响因子：
4.2
作者：
Kelleher, SL;Lönnerdal, B
通讯作者：
Lönnerdal, B
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3.5
作者：
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2.3
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5.5
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2.5
作者：
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