Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus.
Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus.
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DOI：
10.1038/ncomms13579
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发表时间：
2016-12-08
影响因子：
16.6
通讯作者：
Delogu, Alessio
中科院分区：
文献类型：
--
作者：
Jager, Polona;Ye, Zhiwen;Yu, Xiao;Zagoraiou, Laskaro;Prekop, Hong-Ting;Partanen, Juha;Jessell, Thomas M.;Wisden, William;Brickley, Stephen G.;Delogu, Alessio
GABA从背外侧膝状体核（dLGN-INs）中的局部中间神经元的释放在丘脑内的视觉处理期间提供抑制控制。人们通常认为，这类重要的中间神经元起源于丘脑复合体内，但我们现在表明，在出生后发育早期，Sox 14/Otx 2表达的前体细胞迁移从背侧中脑产生dLGN-INs. The意想不到的外间脑起源dLGN-INs设置他们除了网状丘脑核的GABA能神经元。使用光遗传学，我们表明，在增加的放电率顶盖衍生的dLGN-IN产生一个强大的形式的紧张性抑制，调节通过募集突触外高亲和力GABAA受体的丘脑中继神经元的增益。因此，通过修改丘脑中间神经元个体发育的传统观点，我们证明了以前不受重视的中脑人口控制丘脑中继神经元的兴奋性。 丘脑中间神经元的发育和功能仅部分了解。在这里，作者描述了意想不到的中脑起源的GABA能中间神经元的视觉丘脑，提供相位和紧张性调制丘脑中继神经元的兴奋性。
The release of GABA from local interneurons in the dorsal lateral geniculate nucleus (dLGN-INs) provides inhibitory control during visual processing within the thalamus. It is commonly assumed that this important class of interneurons originates from within the thalamic complex, but we now show that during early postnatal development Sox14/Otx2-expressing precursor cells migrate from the dorsal midbrain to generate dLGN-INs. The unexpected extra-diencephalic origin of dLGN-INs sets them apart from GABAergic neurons of the reticular thalamic nucleus. Using optogenetics we show that at increased firing rates tectal-derived dLGN-INs generate a powerful form of tonic inhibition that regulates the gain of thalamic relay neurons through recruitment of extrasynaptic high-affinity GABAA receptors. Therefore, by revising the conventional view of thalamic interneuron ontogeny we demonstrate how a previously unappreciated mesencephalic population controls thalamic relay neuron excitability. The development and function of thalamic interneurons is only partially understood. Here the authors describe the unexpected mesencephalic origin of the GABAergic interneurons of the visual thalamus that provide both phasic and tonic modulation of thalamic relay neuron excitability.
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影响因子：
13.9
作者：
Fishell G;Rudy B
通讯作者：
Rudy B
影响因子：
16.2
作者：
Acuna-Goycolea, Claudio;Brenowitz, Stephan D.;Regehr, Wade G.
通讯作者：
Regehr, Wade G.
影响因子：
64.8
作者：
Gueler, Ali D.;Ecker, Jennifer L.;Hattar, Samer
通讯作者：
Hattar, Samer
影响因子：
5.3
作者：
Casale, Amanda E.;McCormick, David A.
通讯作者：
McCormick, David A.
影响因子：
56.9
作者：
Hensch, TK;Stryker, MP
通讯作者：
Stryker, MP