A neural mechanism for exacerbation of headache by light.
A neural mechanism for exacerbation of headache by light.
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DOI：
10.1038/nn.2475
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发表时间：
2010-02
影响因子：
25
通讯作者：
Burstein, Rami
中科院分区：
文献类型：
--
作者：
Noseda, Rodrigo;Kainz, Vanessa;Jakubowski, Moshe;Gooley, Joshua J.;Saper, Clifford B.;Digre, Kathleen;Burstein, Rami
偏头痛的感觉是由从硬脑膜传递到大脑的伤害性信号介导的，暴露在光下会加剧偏头痛的感觉。在这里，我们表明，偏头痛加重轻是普遍的盲人谁保持非图像形成光调节在面对大量杆/锥变性。在大鼠中使用单单位记录和神经束追踪，我们确定了后丘脑中的硬脑膜敏感神经元，其活动明显受到光的调制，其轴突广泛地投射在I层至V层的躯体感觉、视觉和联想皮层。这种硬脑膜/光敏神经元的细胞体和树突由源自视网膜神经节细胞的轴突并置，主要来自本质光敏视网膜神经节细胞-非图像形成光调节的主要管道。我们认为偏头痛的光调节作用是由一个非成像视网膜通路来调节硬脑膜敏感的丘脑皮质神经元的活动。
The perception of migraine headache, which is mediated by nociceptive signals transmitted from the cranial dura mater to the brain, is uniquely exacerbated by exposure to light. Here we show that exacerbation of migraine headache by light is prevalent among blind persons who maintain non-image-forming photoregulation in the face of massive rod/cone degeneration. Using single-unit recording and neural tract-tracing in the rat, we identified dura-sensitive neurons in the posterior thalamus, whose activity was distinctly modulated by light, and whose axons projected extensively across layers I through V of somatosensory, visual and associative cortices. The cell bodies and dendrites of such dura/light-sensitive neurons were apposed by axons originating from retinal ganglion cells, predominantly from intrinsically-photosensitive retinal ganglion cells – the principle conduit of non-image-forming photoregulation. We propose that photoregulation of migraine headache is exerted by a non-image-forming retinal pathway that modulates the activity of dura-sensitive thalamocortical neurons.
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