Prenatal exposure to the pesticide DDT and hypertension diagnosed in women before age 50: a longitudinal birth cohort study.
Prenatal exposure to the pesticide DDT and hypertension diagnosed in women before age 50: a longitudinal birth cohort study.
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DOI：
10.1289/ehp.1205921
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发表时间：
2013-05
影响因子：
10.4
通讯作者：
Cohn BA
中科院分区：
文献类型：
--
作者：
La Merrill M;Cirillo PM;Terry MB;Krigbaum NY;Flom JD;Cohn BA
背景：在成人研究中，杀虫剂DDT(二氯二苯基三氯乙烷)水平升高与血压和高血压呈正相关。越来越多的流行病学和毒理学证据表明，成年期的高血压也可能受到早期生活的影响，可能还会受到产前环境的影响。目的：我们评估了产前接触杀虫剂DDT是否会增加成人高血压的风险。方法：我们检测了1959年至1967年间在旧金山湾区参加儿童健康与发育研究出生队列的一组妇女(n=527)的产前血清样本中DDT(p，p‘-和o，p’-)及其代谢物p，p‘-DDE(二氯二苯基二氯乙烯)的浓度。我们从2005年到2008年通过电话访谈对39-47岁的女儿进行了调查，以获得关于医生自我报告的高血压和高血压药物使用的信息。我们使用基于COX比例风险模型的高血压发病时间的多变量回归分析来估计产前DDT暴露与成年后用药治疗的高血压之间的相关性的相对比率，并调整了母亲、早期生活和成人暴露的潜在混杂。结果：产前p，p‘-DDT暴露与高血压相关[调整危险比(AHR)=3.6；95%CI：1.8、7.2和AHR=2.5；p，p’-DDT中、高剂量组与最低剂量组比较，95%CI分别为1.2、5.3]。P，p‘-DDT和高血压之间的这些关联对于独立的高血压危险因素的调整以及敏感性分析是强有力的。结论：这些发现表明，DDT暴露与高血压之间的联系可能起源于早期的发展。
Background: Elevated levels of the pesticide DDT (dichlorodiphenyltrichloroethane) have been positively associated with blood pressure and hypertension in studies among adults. Accumulating epidemiologic and toxicologic evidence suggests that hypertension during adulthood may also be affected by earlier life and possibly the prenatal environment. Objectives: We assessed whether prenatal exposure to the pesticide DDT increases risk of adult hypertension. Methods: We examined concentrations of DDT (p,p´- and o,p´-) and its metabolite p,p´-DDE (dichlorodiphenyldichloroethylene) in prenatal serum samples from a subset of women (n = 527) who had participated in the prospective Child Health and Development Studies birth cohort in the San Francisco Bay area while they were pregnant between 1959 and 1967. We surveyed daughters 39–47 years of age by telephone interview from 2005 to 2008 to obtain information on self-reported physician-diagnosed hypertension and use of hypertensive medication. We used multivariable regression analysis of time to hypertension based on the Cox proportional hazards model to estimate relative rates for the association between prenatal DDT exposures and hypertension treated with medication in adulthood, with adjustment for potential confounding by maternal, early-life, and adult exposures. Results: Prenatal p,p´-DDT exposure was associated with hypertension [adjusted hazard ratio (aHR) = 3.6; 95% CI: 1.8, 7.2 and aHR = 2.5; 95% CI: 1.2, 5.3 for middle and high tertiles of p,p´-DDT relative to the lowest tertile, respectively]. These associations between p,p´-DDT and hypertension were robust to adjustment for independent hypertension risk factors as well as sensitivity analyses. Conclusions: These findings suggest that the association between DDT exposure and hypertension may have its origins early in development.
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作者：
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通讯作者：
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影响因子：
10.4
作者：
Cohn BA;Wolff MS;Cirillo PM;Sholtz RI
通讯作者：
Sholtz RI