In situ 3D magnetic resonance metabolic imaging of microwave-irradiated rodent brain: a new tool for metabolomics research.
In situ 3D magnetic resonance metabolic imaging of microwave-irradiated rodent brain: a new tool for metabolomics research.
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微波照射啮齿动物大脑的原位 3D 磁共振代谢成像：代谢组学研究的新工具。
DOI：
10.1111/j.1471-4159.2009.05967.x
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发表时间：
2009-04
影响因子：
4.7
通讯作者：
Behar KL
中科院分区：
文献类型：
--
作者：
de Graaf RA;Chowdhury GM;Brown PB;Rothman DL;Behar KL
The rapid elevation in rat brain temperature achieveable with focused beam microwave irradiation (FBMI) leads to a permanent inactivation of enzymes, thereby minimizing enzyme-dependent post mortem metabolic changes. An additional characteristic of FBMI is that the NMR properties of the tissue are close to those of the in vivo condition and remain so for at least 12 hours. These features create an opportunity to develop MRI and MRS on microwave-irradiated samples into a technique with a resolution, coverage and sensitivity superior to any experiment performed directly in vivo. Furthermore, when combined with pre-FBMI infusion of 13C-labeled substrates, like [1-13C]-glucose, the technique can generate maps of metabolic fluxes, like the TCA and glutamate-glutamine neurotransmitter cycle fluxes at an unprecedented spatial resolution.
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影响因子：
6.3
作者：
Chowdhury, Golam M. I.;Banasr, Mounira;Sanacora, Gerard
通讯作者：
Sanacora, Gerard
影响因子：
2.2
作者：
Garwood, M;DelaBarre, L
通讯作者：
DelaBarre, L
影响因子：
4.7
作者：
BALCOM, GJ;LENOX, RH;MEYERHOFF, JL
通讯作者：
MEYERHOFF, JL
影响因子：
3
作者：
THEODORSSON, E;STENFORS, C;MATHE, AA
通讯作者：
MATHE, AA
影响因子：
4.7
作者：
Hunsucker, Stephen W.;Solomon, Benjamin;Patterson, David
通讯作者：
Patterson, David