Salience network functional connectivity is spatially heterogeneous across sensorimotor cortex in healthy humans.
Salience network functional connectivity is spatially heterogeneous across sensorimotor cortex in healthy humans.
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DOI：
10.1016/j.neuroimage.2020.117177
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发表时间：
2020-11-01
期刊：
影响因子：
5.7
通讯作者：
Kutch JJ
中科院分区：
文献类型：
--
作者：
Hegarty AK;Yani MS;Albishi A;Michener LA;Kutch JJ
显着性网络在一系列需要立即行为反应的条件下做出反应，包括疼痛处理。慢性疼痛中显著性网络与感觉运动皮层的静息状态功能连接发生改变。然而，很少有人了解他们在没有疼痛的情况下的基本沟通。在这项研究中，我们映射了健康个体感觉运动皮层的显著性网络静息状态功能连接。使用肌电图和基于任务的功能性磁共振成像（fMRI），我们首先定位不同的区域感兴趣的内侧（臀），中间（肩）和外侧（手）区域的感觉运动皮层。然后，我们使用两个队列（主要和复制）的健康人从公共存储库的静息状态功能磁共振成像映射显着性网络静息状态功能连接整个感觉运动皮层。主要和复制队列表现出显着的异质性，在整个感兴趣的感觉运动区域的显着网络休息状态功能连接。使用皮质平面图可视化整个感觉运动表面，我们观察到类似的异质性在两个队列。在一般情况下，近端身体区域（躯干/面部）的躯体位置表示具有较高的显着性网络静息态功能连接相比，远端身体区域（上/下肢）。我们的结论是，感觉运动皮层是空间异质性在其与健康个体的显着性网络的相互作用。
The salience network is responsive during a range of conditions requiring immediate behavioral responses, including pain processing. Resting-state functional connectivity of the salience network to the sensorimotor cortex is altered in chronic pain. However, little is understood about their fundamental communication in the absence of pain. In this study, we mapped salience network resting-state functional connectivity across sensorimotor cortex in healthy individuals. Using electromyography and task-based functional magnetic resonance imaging (fMRI), we first localized distinct regions-of-interest across sensorimotor cortex in medial (gluteal), intermediate (shoulder), and lateral (hand) areas. We then used resting-state fMRI for two cohorts (primary and replication) of healthy individuals from public repositories to map salience network resting-state functional connectivity across sensorimotor cortex. Both the primary and replication cohorts exhibited significant heterogeneity in salience network resting-state functional connectivity across the sensorimotor regions-of-interest. Using a cortical flatmap to visualize the entire sensorimotor surface, we observed similar heterogeneity in both cohorts. In general, the somatotopic representation of proximal body regions (trunk/face) had higher salience network resting-state functional connectivity compared to distal body regions (upper/lower limbs). We conclude that sensorimotor cortex is spatially heterogeneous in its interaction with the salience network in healthy individuals.
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82.9
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