Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage.
Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage.
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DOI：
10.1038/nn1620
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发表时间：
2006-03
影响因子：
25
通讯作者：
Richardson WD
中科院分区：
文献类型：
--
作者：
Kessaris N;Fogarty M;Iannarelli P;Grist M;Wegner M;Richardson WD
前脑少突胶质细胞祖细胞（OLPs）的发育起源一直存在争议。现在，我们通过转基因小鼠的Cre-lox命运图谱显示，第一批olp起源于前脑腹侧的内侧神经节隆起（MGE）和前针束内区（AEP）。从那里，它们在第二波来自侧和/或尾神经节突起（LGE和CGE）的olp加入之前，填充整个胚胎端脑，包括大脑皮层。最后，第三波出现在出生后的大脑皮层。当任何一个种群被白喉毒素的靶向表达从源头上破坏时，剩余的细胞接管，小鼠存活并表现正常，具有正常的少突胶质细胞和髓磷脂补体。因此，功能冗余的olp群体在发育中的大脑中竞争空间。引人注目的是，胚胎MGE和aep衍生的种群在出生后的生活中被淘汰，这引发了对竞争性质和目的的质疑。
The developmental origin of oligodendrocyte progenitors (OLPs) in the forebrain has been controversial. We now show, by Cre-lox fate mapping in transgenic mice, that the first OLPs originate in the medial ganglionic eminence (MGE) and anterior entopeduncular area (AEP) in the ventral forebrain. From there, they populate the entire embryonic telencephalon including the cerebral cortex before being joined by a second wave of OLPs from the lateral and/or caudal ganglionic eminences (LGE and CGE). Finally, a third wave arises within the postnatal cortex. When any one population is destroyed at source by targeted expression of Diphtheria toxin, the remaining cells take over and the mice survive and behave normally, with a normal complement of oligodendrocytes and myelin. Thus, functionally redundant populations of OLPs compete for space in the developing brain. Strikingly, the embryonic MGE- and AEP-derived population is eliminated during postnatal life, raising questions about the nature and purpose of the competition.
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