Nephron number and its determinants: a 2020 update.

Nephron number and its determinants: a 2020 update.
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DOI:
10.1007/s00467-020-04534-2
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发表时间:
2021-04
期刊:
Pediatric nephrology (Berlin, Germany)
影响因子:
--
通讯作者:
Bennett KM
Bennett KM
中科院分区:
其他
文献类型:
--
作者:
Charlton JR;Baldelomar EJ;Hyatt DM;Bennett KM

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Studies of human nephron number have been conducted for well over a century and have uncovered the large variability in nephron number. However, the mechanisms influencing nephron endowment and loss along with the etiology for the wide range amongst individuals is largely unknown. Advances in imaging technology have allowed investigators to revisit the principles of renal structure and physiology and their roles in the progression of kidney disease. Here, we will review the latest data on the influences impacting nephron number, innovations made over the last six years to understand and integrate renal structure and function, and new developments in the tools used to count nephrons in vivo.
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