Plasma microRNA levels differ between endurance and strength athletes.
Plasma microRNA levels differ between endurance and strength athletes.
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DOI：
10.1371/journal.pone.0122107
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Moran CN
中科院分区：
文献类型：
--
作者：
Wardle SL;Bailey ME;Kilikevicius A;Malkova D;Wilson RH;Venckunas T;Moran CN
microRNA（miRNAs）在循环中是稳定的，并且可能在涉及基因表达变化的各种代谢反应（包括运动训练）期间在器官间通信中起作用。然而，目前还不清楚循环miRNA（c-miRNA）水平的差异是否是训练模式的特征。我们调查了两种不同训练方式（每组n = 10）-耐力（END）和力量（STR）-的优秀男性运动员之间以及这些组与未经训练的对照组（CON; n = 10）之间候选c-miRNAs的水平是否存在差异。分析空腹、未运动的早晨血浆样品的14种c-miRNA（miR-1、miR-16-2、miR-20 a-1、miR-21、miR-93、miR-103 a、miR-133 a、miR-146 a、miR-192、miR-206、miR-221、miR-222、miR-451、miR-499）。此外，我们研究了c-miRNA水平是否与组内和组间的定量表现相关表型相关。miR-222在三个参与者组中以不同水平存在（p = 0.028），在END中观察到最高水平，在STR中观察到最低水平。（相对于STR，± 1 SEM; miR-222：1.94倍（1.73-2.18），p = 0.011; miR-21：1.56倍（1.39-1.74），p = 0.013; miR-146 a：1.50倍（1.38-1.64），p = 0.019; miR-221：1.51倍（1.34-1.70），p = 0.026）。回归分析显示，在调整肌肉或脂肪质量之前和之后，候选c-miRNA水平与力量相关性能指标之间存在若干相关性，但在调整组后则无相关性。某些c-miRNA（miR-222、miR-21、miR-146 a和miR-221）在耐力训练和阻力训练的运动员之间不同，因此具有作为运动训练的有用生物标志物的潜力和/或在运动模式特异性训练适应中发挥作用。然而，这些c-miRNAs的水平可能与肌肉体积或脂肪储备无关。
MicroRNAs (miRNAs) are stable in the circulation and are likely to function in inter-organ communication during a variety of metabolic responses that involve changes in gene expression, including exercise training. However, it is unknown whether differences in circulating-miRNA (c-miRNA) levels are characteristic of training modality. We investigated whether levels of candidate c-miRNAs differ between elite male athletes of two different training modalities (n = 10 per group) - endurance (END) and strength (STR) - and between these groups and untrained controls (CON; n = 10). Fasted, non-exercised, morning plasma samples were analysed for 14 c-miRNAs (miR-1, miR-16-2, miR-20a-1, miR-21, miR-93, miR-103a, miR-133a, miR-146a, miR-192, miR-206, miR-221, miR-222, miR-451, miR-499). Moreover, we investigated whether c-miRNA levels were associated with quantitative performance-related phenotypes within and between groups. miR-222 was present at different levels in the three participant groups (p = 0.028) with the highest levels being observed in END and the lowest in STR. A number of other c-miRNAs were present at higher levels in END than in STR (relative to STR, ± 1 SEM; miR-222: 1.94 fold (1.73-2.18), p = 0.011; miR-21: 1.56 fold (1.39-1.74), p = 0.013; miR-146a: 1.50 fold (1.38-1.64), p = 0.019; miR-221: 1.51 fold (1.34-1.70), p = 0.026). Regression analyses revealed several associations between candidate c-miRNA levels and strength-related performance measures before and after adjustment for muscle or fat mass, but not following adjustment for group. Certain c-miRNAs (miR-222, miR-21, miR-146a and miR-221) differ between endurance- and resistance-trained athletes and thus have potential as useful biomarkers of exercise training and / or play a role in exercise mode-specific training adaptations. However, levels of these c-miRNAs are probably unrelated to muscle bulk or fat reserves.
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影响因子：
3.3
作者：
Baggish, Aaron L.;Park, Joseph;Chan, Stephen Y.
通讯作者：
Chan, Stephen Y.
影响因子：
3.7
作者：
Lu TP;Lee CY;Tsai MH;Chiu YC;Hsiao CK;Lai LC;Chuang EY
通讯作者：
Chuang EY
影响因子：
3.7
作者：
Bye A;Røsjø H;Aspenes ST;Condorelli G;Omland T;Wisløff U
通讯作者：
Wisløff U
DOI：
10.1152/ajpheart.00711.2013
发表时间：
2014-02-15
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Mooren FC;Viereck J;Krüger K;Thum T
通讯作者：
Thum T
影响因子：
5.5
作者：
Baggish, Aaron L.;Hale, Andrew;Chan, Stephen Y.
通讯作者：
Chan, Stephen Y.