Disorganization of Semantic Brain Networks in Schizophrenia Revealed by fMRI.
Disorganization of Semantic Brain Networks in Schizophrenia Revealed by fMRI.
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DOI：
10.1093/schbul/sbac157
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发表时间：
2023-03-15
影响因子：
6.6
通讯作者：
Takahashi, Hidehiko
中科院分区：
文献类型：
--
作者：
Matsumoto, Yukiko;Nishida, Satoshi;Hayashi, Ryusuke;Son, Shuraku;Murakami, Akio;Yoshikawa, Naganobu;Ito, Hiroyoshi;Oishi, Naoya;Masuda, Naoki;Murai, Toshiya;Friston, Karl;Nishimoto, Shinji;Takahashi, Hidehiko
精神分裂症是一种精神疾病，表现为思维障碍，包括妄想和言语混乱。自从布莱希特首次创造了“精神分裂症”这个术语以来，思维障碍一直被认为是语义概念之间联系松散的结果。然而，这种主要的功能失调失调的机制帐户一直缺乏。为了评估异常语义连接是如何通过大脑活动表达的，我们使用功能性磁共振成像（fMRI）表征了概念表征的大规模网络结构。我们使用编码模型从电影场景诱发的功能磁共振成像活动中量化了患者大脑中的各种概念表征。然后，我们通过评估这些语义表征的相似性来构建语义脑网络，并进行基于图论的网络分析。神经网络具有与自然语言相似的小世界特性，这表明小世界性是语义知识网络的普遍特性。相反，精神分裂症患者网络中的小世界性显著降低，并且与妄想的心理测量相关。与对照组相比，患者的语义网络被划分为更明显的类别，并且具有更多随机的类别内结构。概念表征的差异表现为改变的语义聚类和联想入侵，这些都是思维障碍的基础。这是第一个研究提供的松散的协会，反映在随机化的语义网络精神分裂症的病理生理学证据。我们的方法提供了一个很有前途的方法来理解神经基础的改变或创造性的内部经验的个人精神疾病或特殊能力，分别。
Schizophrenia is a mental illness that presents with thought disorders including delusions and disorganized speech. Thought disorders have been regarded as a consequence of the loosening of associations between semantic concepts since the term “schizophrenia” was first coined by Bleuler. However, a mechanistic account of this cardinal disturbance in terms of functional dysconnection has been lacking. To evaluate how aberrant semantic connections are expressed through brain activity, we characterized large-scale network structures of concept representations using functional magnetic resonance imaging (fMRI). We quantified various concept representations in patients’ brains from fMRI activity evoked by movie scenes using encoding modeling. We then constructed semantic brain networks by evaluating the similarity of these semantic representations and conducted graph theory-based network analyses. Neurotypical networks had small-world properties similar to those of natural languages, suggesting small-worldness as a universal property in semantic knowledge networks. Conversely, small-worldness was significantly reduced in networks of schizophrenia patients and was correlated with psychological measures of delusions. Patients’ semantic networks were partitioned into more distinct categories and had more random within-category structures than those of controls. The differences in conceptual representations manifest altered semantic clustering and associative intrusions that underlie thought disorders. This is the first study to provide pathophysiological evidence for the loosening of associations as reflected in randomization of semantic networks in schizophrenia. Our method provides a promising approach for understanding the neural basis of altered or creative inner experiences of individuals with mental illness or exceptional abilities, respectively.
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影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
抗精神病药 - 不依次的第一集精神分裂症中固有连通性网络的改变。
影响因子：
6.6
作者：
Anhøj S;Ødegaard Nielsen M;Jensen MH;Ford K;Fagerlund B;Williamson P;Glenthøj B;Rostrup E
通讯作者：
Rostrup E
DOI：
10.1113/jp271707
发表时间：
2016-04-01
期刊：
The Journal of physiology
影响因子：
--
作者：
Allen AE;Procyk CA;Howarth M;Walmsley L;Brown TM
通讯作者：
Brown TM
影响因子：
5.4
作者：
De Deyne, Simon;Storms, Gert
通讯作者：
Storms, Gert
影响因子：
10.6
作者：
Cho, Kang Ik K.;Kwak, Yoo Bin;Kwon, Jun Soo
通讯作者：
Kwon, Jun Soo