Sex differences in murine susceptibility to systemic viral infections.
Sex differences in murine susceptibility to systemic viral infections.
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DOI：
10.1016/j.jaut.2011.12.003
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发表时间：
2012-05
影响因子：
12.8
通讯作者：
French AR
中科院分区：
文献类型：
--
作者：
Geurs TL;Hill EB;Lippold DM;French AR
女性对自身免疫的易感性增加通常被视为免疫反应性增强的结果，提供了针对感染的卓越保护。矛盾的是，我们观察到，在三种大型双链 DNA 病毒（I 型单纯疱疹病毒 [HSV]、鼠巨细胞病毒 [MCMV] 和痘苗病毒 [VV]）全身病毒感染期间，雌性小鼠的死亡率高于雄性小鼠。事实上，雌性小鼠对 HSV 感染的易感性比雄性小鼠高 27 倍。通过雌性小鼠卵巢切除术消除雌激素或向去势雄性小鼠添加雌激素只能部分消除HSV感染后观察到的性别差异。然而，在缺乏 I 型干扰素受体信号传导的情况下，雌性和雄性小鼠之间观察到的生存差异几乎被消除，而在没有 DAP12 信号传导的情况下则大大减轻。有趣的是，I 型干扰素受体和 DAP12 信号传导对性别特异性的影响对全身病毒感染期间的存活率产生了不同的影响，其中 I 型干扰素受体信号传导增强了雄性小鼠的存活率，而 DAP12 信号传导增加了雌性小鼠的易感性。这些结果对人类自身免疫性疾病中观察到的性别差异具有潜在影响。
Increased susceptibility to autoimmunity in females is often viewed as the consequence of enhanced immunoreactivity providing superior protection against infections. We paradoxically observed greater mortality in female compared to male mice during systemic viral infections with three large double-stranded DNA viruses (herpes simplex virus type I [HSV], murine cytomegalovirus [MCMV], and vaccinia virus [VV]). Indeed, female mice were 27-fold more susceptible to infection with HSV than male mice. Elimination of estrogen by ovariectomy in female mice or addition of estrogen to castrated male mice only partially eliminated the observed sex differences following HSV infection. However, the differences observed in survival between female and male mice were nearly abrogated in the absence of type I interferon receptor signaling and substantially mitigated in absence of DAP12 signaling. Interestingly, the sex-specific impact of type I interferon receptor and DAP12 signaling differentially influenced survival during systemic viral infections with type I interferon receptor signaling enhancing male survival and DAP12 signaling increasing the susceptibility of female mice. These results have potential implications for the sex disparities observed in human autoimmune disorders.
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影响因子：
6.4
作者：
Camara, Makhtar;Dieye, Tandakha Ndiaye;Jennes, Wim
通讯作者：
Jennes, Wim
影响因子：
7.4
作者：
Arnold, Arthur P.;Chen, Xuqi
通讯作者：
Chen, Xuqi
影响因子：
56.9
作者：
Brown, MG;Dokun, AO;Yokoyama, WM
通讯作者：
Yokoyama, WM
影响因子：
5.5
作者：
Kennedy RB;Ovsyannikova IG;Pankratz VS;Vierkant RA;Jacobson RM;Ryan MA;Poland GA
通讯作者：
Poland GA
影响因子：
5.4
作者：
Huber, SA
通讯作者：
Huber, SA