Enhancing panic and smoking reduction treatment with d-cycloserine: Study protocol for a randomized controlled trial.

Enhancing panic and smoking reduction treatment with d-cycloserine: Study protocol for a randomized controlled trial.
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使用 d-环丝氨酸加强恐慌和减少吸烟治疗:随机对照试验的研究方案。

DOI:
10.1016/j.cct.2016.03.011
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发表时间:
2016
影响因子:
2.2
通讯作者:
Rosenfield,David
Rosenfield,David
中科院分区:
医学4区
文献类型:
--
作者:
Smits,JasperAJ;Kauffman,BrookeY;Lee-Furman,Eunjung;Zvolensky,MichaelJ;Otto,MichaelW;Piper,MeganE;Powers,MarkB;Rosenfield,David

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尽管吸烟者的复发风险增加,但相对较少关注恐慌发作的治疗策略。恐慌和吸烟减少治疗(PSRT)将标准戒烟治疗与针对恐慌-吸烟关系潜在机制的基于焦虑的干预相结合。基于支持d-环丝氨酸(DCS)用于增强基于胰岛素的治疗的疗效的新证据,我们正在进行DCS用于增强PSRT结局的疗效的初步测试。利用一项比较PSRT + DCS与PSRT +安慰剂的随机、双盲试验,我们将获得短期和长期戒烟结局的初始效应量,并对假定机制进行初步检验。
There has been relatively little attention focused on treatment strategies for smokers with panic attacks despite their increased risk of relapse. Panic and Smoking Reduction Treatment (PSRT) integrates standard smoking cessation treatment with an exposure-based intervention targeting the mechanisms underlying panic-smoking relations. Building upon emerging evidence supporting the efficacy of d-cycloserine (DCS) for augmenting exposure-based therapy, we are conducting an initial test of the efficacy of DCS for enhancing PSRT outcomes. Utilizing a randomized, double-blind trial comparing PSRT + DCS to PSRT + placebo, we will obtain initial effect sizes for short-term and long-term smoking cessation outcomes and perform an initial test of putative mechanisms.
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