Of blood cells and the nervous system: hematopoiesis in the Drosophila larva.
Of blood cells and the nervous system: hematopoiesis in the Drosophila larva.
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作者：
Makhijani K;Brückner K
造血功能在果蝇和脊椎动物之间保存良好。与脊椎动物相似，在果蝇的发育过程中，造血部位也发生了变化。血细胞（血细胞）在胚胎和果蝇淋巴腺的造血波中从头产生。相比之下，幼虫的造血波是基于胚胎中产生的分化血细胞对常驻造血部位的定植，就像脊椎动物中卵黄囊的原始巨噬细胞对外周组织的定植，或者造血干细胞和祖细胞对胎儿肝脏、脾脏和骨髓的播种。在向幼虫阶段过渡时，果蝇胚胎血细胞退回到造血“壁龛”，即幼虫体壁上与感觉神经元和周围神经系统（PNS）的其他细胞共同共享的节段重复的造血口袋。血细胞的定位和生存依赖于PNS，并在这些微环境中被诱导增殖，扩大形成幼虫造血系统。在这个过程中，胚胎中分化的血细胞恢复增殖和自我更新，不需要未分化的原血细胞祖细胞。幼虫造血是PNS支持血细胞定植和生态位的第一个果蝇模型。它提示了一个界面，其中无害或有害的感觉输入调节血细胞稳态或免疫反应。该系统增加了神经系统对造血微环境和器官干细胞壁龛的依赖性这一日益增长的概念，这一概念正在跨门发现。
Hematopoiesis is well-conserved between Drosophila and vertebrates. Similar as in vertebrates, the sites of hematopoiesis shift during Drosophila development. Blood cells (hemocytes) originate de novo during hematopoietic waves in the embryo and in the Drosophila lymph gland. In contrast, the hematopoietic wave in the larva is based on the colonization of resident hematopoietic sites by differentiated hemocytes that arise in the embryo, much like in vertebrates the colonization of peripheral tissues by primitive macrophages of the yolk sac, or the seeding of fetal liver, spleen and bone marrow by hematopoietic stem and progenitor cells. At the transition to the larval stage, Drosophila embryonic hemocytes retreat to hematopoietic “niches,” i.e., segmentally repeated hematopoietic pockets of the larval body wall that are jointly shared with sensory neurons and other cells of the peripheral nervous system (PNS). Hemocytes rely on the PNS for their localization and survival, and are induced to proliferate in these microenvironments, expanding to form the larval hematopoietic system. In this process, differentiated hemocytes from the embryo resume proliferation and self-renew, omitting the need for an undifferentiated prohemocyte progenitor. Larval hematopoiesis is the first Drosophila model for blood cell colonization and niche support by the PNS. It suggests an interface where innocuous or noxious sensory inputs regulate blood cell homeostasis or immune responses. The system adds to the growing concept of nervous system dependence of hematopoietic microenvironments and organ stem cell niches, which is being uncovered across phyla.
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影响因子：
9.2
作者：
Clark, Rebecca I.;Woodcock, Katie J.;Geissmann, Frederic;Trouillet, Celine;Dionne, Marc S.
通讯作者：
Dionne, Marc S.
影响因子：
2.3
作者：
Evans, CJ;Banerjee, U
通讯作者：
Banerjee, U
影响因子：
2.7
作者：
Ferjoux, Geraldine;Auge, Benoit;Waltzer, Lucas
通讯作者：
Waltzer, Lucas
DOI：
10.1073/pnas.0709951105
发表时间：
2008-07-22
影响因子：
11.1
作者：
Babcock, Daniel T.;Brock, Amanda R.;Galko, Michael J.
通讯作者：
Galko, Michael J.
影响因子：
16.2
作者：
BODMER, R;CARRETTO, R;JAN, YN
通讯作者：
JAN, YN