Adolescent sex differences in cortico-subcortical functional connectivity during response inhibition.
Adolescent sex differences in cortico-subcortical functional connectivity during response inhibition.
复制标题
响应抑制期间皮质增生功能连通性的青少年性别差异。
DOI：
10.3758/s13415-019-00718-y
复制
发表时间：
2020-02
期刊：
影响因子：
--
通讯作者：
Stevens MC
中科院分区：
文献类型：
--
作者：
Chung YS;Calhoun V;Stevens MC
大量的证据表明，在反应抑制任务中参与的认知过程与额顶网络内区域的结构和功能整合有关。然而，虽然先前的研究已经开始表征男孩和女孩之间在静息状态下的内在连接性如何不同，但当大脑功能由典型的Go/No-Go任务的处理需求（评估反应抑制和错误处理）外源驱动时，对男性和女性之间的功能连接性如何不同知之甚少。本研究的目的是描述青少年的性别差异和可能的变化，在青少年发展中的性二态性区域功能连接在皮质和皮质下的大脑连接在视觉去/不去任务引起的。共有130名健康青少年（年龄12-25岁）在功能性磁共振成像过程中执行Go/No-Go任务。高模型阶组独立成分分析被用来表征反应抑制过程中的全脑网络功能连接，然后使用单变量技术来评估与性别和年龄相关的差异。正如预测和类似于先前描述的结果，从非任务驱动的静息状态连接的研究，功能连接的性别差异，观察到在几个皮层下区域，包括杏仁核，尾状核，丘脑和皮质区，包括额下回参与最强烈的成功反应抑制和/或错误处理。重要的是，青春期的男孩和女孩表现出不同的规范配置文件的年龄相关的变化，在几个默认模式的区域和前扣带皮层网络。这些结果表明，支持反应抑制的皮质-皮质下功能网络在青春期男女之间的运作方式不同。
Numerous lines of evidence have shown that cognitive processes engaged during response inhibition tasks are associated with structure and functional integration of regions within frontoparietal networks. However, while prior studies have started to characterize how intrinsic connectivity during resting state differs between boys and girls, comparatively less is known about how functional connectivity differs between males and females when brain function is exogenously driven by the processing demands of typical Go/No-Go tasks that assess both response inhibition and error processing. The purpose of this study was to characterize adolescent sex differences and possible changes in sexually-dimorphic regional functional connectivity across adolescent development in both cortical and subcortical brain connectivity elicited during a visual Go/No-Go task. A total of 130 healthy adolescents (ages 12–25 years) performed a Go/No-Go task during functional magnetic resonance imaging. High model-order group independent component analysis was used to characterize whole-brain network functional connectivity during response inhibition and then a univariate technique used to evaluate differences related to sex and age. As predicted and similar to previously described findings from non-task driven resting state connectivity studies, functional connectivity sex differences were observed in several subcortical regions, including the amygdala, caudate, thalamus and cortical regions including inferior frontal gyrus engaged most strongly during successful response inhibition and/or error processing. Importantly, adolescent boys and girls exhibited different normative profiles of age-related changes in several default mode networks of regions and anterior cingulate cortex. These results suggest that cortical-subcortical functional networks supporting response inhibition operate differently between sexes during adolescence.
登录
查看更多内容
影响因子：
5.7
作者：
Alarcón G;Cservenka A;Rudolph MD;Fair DA;Nagel BJ
通讯作者：
Nagel BJ
影响因子：
2.5
作者：
Andrews-Hanna, Jessica R.;Reidler, Jay S.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
1.7
作者：
Bluhm, Robyn L.;Osuch, Elizabeth A.;Williamson, Peter
通讯作者：
Williamson, Peter
影响因子：
6.6
作者：
Casey, B. J.;Getz, Sarah;Galvan, Adriana
通讯作者：
Galvan, Adriana
影响因子：
17.6
作者：
Calhoun VD;Adalı T
通讯作者：
Adalı T