Metabolic networks in epilepsy by MR spectroscopic imaging.
Metabolic networks in epilepsy by MR spectroscopic imaging.
复制标题
MR光谱成像中癫痫中的代谢网络。
DOI：
10.1111/j.1600-0404.2012.01665.x
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发表时间：
2012-12
影响因子：
3.5
通讯作者：
Spencer SS
中科院分区：
文献类型：
--
作者：
Pan JW;Spencer DD;Kuzniecky R;Duckrow RB;Hetherington H;Spencer SS
癫痫网络的概念很早就从动物和人类的癫痫研究中提出。基于 NAA/Cr 的 MR 光谱成像测量对神经元功能和损伤敏感的普遍观察，我们使用该参数来评估内侧颞叶癫痫 (MTLE) 患者是否存在代谢网络。使用来自 12 个位点（双侧海马、丘脑、基底神经节和岛叶）的 NAA/Cr 测量值，对对照组和 MTLE 患者进行多变量因素分析。因子分析确定这些基因座在代谢上共变的程度和程度。我们提取了两个独立因素来解释对照和 MTLE 患者数据的变异性。在对照中，这些因素表征了“丘脑”和“主导皮质下”功能。除了涉及同侧岛叶和双侧基底神经节的第二个因素外，MTLE 患者还表现出“丘脑”因素。这些数据表明，MTLE 患者表现出涉及丘脑的代谢网络，这在对照组中也可见到。 MTLE 患者还表现出第二组代谢共变区域，这可能是表征边缘系统癫痫发作传播的癫痫网络的表现。
The concept of an epileptic network has long been suggested from both animal and human studies of epilepsy. Based on the common observation that the MR spectroscopic imaging measure of NAA/Cr is sensitive to neuronal function and injury, we use this parameter to assess for the presence of a metabolic network in mesial temporal lobe epilepsy (MTLE) patients. A multivariate factor analysis is performed with controls and MTLE patients, using NAA/Cr measures from 12 loci: the bilateral hippocampi, thalami, basal ganglia, and insula. The factor analysis determines which and to what extent these loci are metabolically covarying. We extract two independent factors that explain the data’s variability in control and MTLE patients. In controls, these factors characterize a ‘thalamic’ and ‘dominant subcortical’ function. The MTLE patients also exhibit a ‘thalamic’ factor, in addition to a second factor involving the ipsilateral insula and bilateral basal ganglia. These data suggest that MTLE patients demonstrate a metabolic network that involves the thalami, also seen in controls. The MTLE patients also display a second set of metabolically covarying regions that may be a manifestation of the epileptic network that characterizes limbic seizure propagation.
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影响因子：
2.5
作者：
Auer, Dorothee P.
通讯作者：
Auer, Dorothee P.
影响因子：
5.6
作者：
Dlugos, DJ;Jaggi, J;Sperling, MR
通讯作者：
Sperling, MR
影响因子：
5.6
作者：
Fisher, Robert;Salanova, Vicenta;Graves, Nina
通讯作者：
Graves, Nina
影响因子：
5.3
作者：
MAGGIO, R;LANAUD, P;GALE, K
通讯作者：
GALE, K
影响因子：
11.2
作者：
Pan, JW;Takahashi, K
通讯作者：
Takahashi, K