Proof-of-concept for characterization of neurodegenerative disorders utilizing two non-REM sleep biomarkers.
Proof-of-concept for characterization of neurodegenerative disorders utilizing two non-REM sleep biomarkers.
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DOI：
10.3389/fneur.2023.1272369
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发表时间：
2023
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
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作者：
这项概念验证研究旨在确定主要在家中获得的两种非快速眼动（NREM）睡眠生物标志物的组合特征是否可以表征不同的神经退行性疾病。在包括对照组（CG = 61）和单独REM睡眠行为障碍的参与者在内的七组中评估睡眠梭形持续时间和非REM张力亢进（NRH（iRBD = 19），轻度认知障碍（MCI = 41）、帕金森病（PD = 16）、阿尔茨海默病痴呆（ADem = 29）、路易体痴呆或帕金森病痴呆（LBD = 19）和进行性核上性麻痹（PSP = 13）。单因素方差分析（ANOVA）、Mann-Whitney U、类内（ICC）和斯皮尔曼等级相关性、Bland-Altman图和Kappa评分、卡方和Fisher精确概率检验以及多元logistic回归主要关注纺锤体持续时间和NRH以及分配给4种正常/异常纺锤体持续时间/NRH组合的频率。方差分析确定了年龄、睡眠效率、REM、NRH（p < 0.0001）和睡眠时间（p = 0.015）的组间差异，纺锤波持续时间和NRH均显示出良好的夜间可靠性（ICC分别为0.95和0.75，Kappa分别为0.93和0.66），并且仅在PD和LBD组中显示出相关性（p < 0.01）。PSP（85%）和LBD（84%）患者的异常纺锤体持续时间高于CG、MCI、PD和ADem（p < 0.025）。与MCI = 32%、ADem = 17%和CG = 16%相比，PSP = 92%、LBD = 79%和iRBD = 74%中的异常NRH更大（p < 0.005）。在CG（56%）和MCI（41%）中最常观察到组合生物标志物正常纺锤体持续时间/正常NRH。ADem最常表现为正常纺锤体持续时间/正常NRH（45%）和异常纺锤体持续时间/正常NRH（38%）。正常纺锤体持续时间/异常NRH在iRBD = 47%中最大，而异常纺锤体持续时间/异常NRH在PSP = 85%和LBD = 74%中占主导地位。NREM睡眠生物标志物纺锤体持续时间和NRH可能有助于区分患有不同神经退行性疾病的患者。需要更大规模的前瞻性队列研究来确定纺锤波持续时间和NRH是否可以结合用于前驱期评估和/或监测疾病进展。
This proof-of-concept study aimed to determine whether the combined features of two non-rapid eye movement (NREM) sleep biomarkers acquired predominantly in-home could characterize different neurodegenerative disorders. Sleep spindle duration and non-REM hypertonia (NRH) were evaluated in seven groups including a control group (CG = 61), and participants with isolated REM sleep behavior disorder (iRBD = 19), mild cognitive impairment (MCI = 41), Parkinson disease (PD = 16), Alzheimer disease dementia (ADem = 29), dementia with Lewy Bodies or Parkinson disease dementia (LBD = 19) and progressive supranuclear palsy (PSP = 13). One-way analysis of variance (ANOVA), Mann–Whitney U, intra-class (ICC) and Spearman ranked correlations, Bland–Altman plots and Kappa scores, Chi-square and Fisher exact probability test, and multiple-logistic regression were focused primarily on spindle duration and NRH and the frequencies assigned to the four normal/abnormal spindle duration/NRH combinations. ANOVA identified group differences in age, sleep efficiency, REM, NRH (p < 0.0001) and sleep time (p = 0.015), Spindle duration and NRH each demonstrated good night-to-night reliabilities (ICC = 0.95 and 0.75, Kappa = 0.93 and 0.66, respectively) and together exhibited an association in the PD and LBD groups only (p < 0.01). Abnormal spindle duration was greater in records of PSP (85%) and LBD (84%) patients compared to CG, MCI, PD and ADem (p < 0.025). Abnormal NRH was greater in PSP = 92%, LBD = 79%, and iRBD = 74% compared to MCI = 32%, ADem = 17%, and CG = 16% (p < 0.005).The combination biomarker normal spindle duration/normal NRH was observed most frequently in CG (56%) and MCI (41%). ADem most frequently demonstrated normal spindle duration/normal NRH (45%) and abnormal spindle duration/normal NRH (38%). Normal spindle duration/abnormal NRH was greatest in iRBD = 47%, while abnormal spindle duration/abnormal NRH was predominant in PSP = 85% and LBD = 74%. The NREM sleep biomarkers spindle duration and NRH may be useful in distinguishing patients with different neurodegenerative disorders. Larger prospective cohort studies are needed to determine whether spindle duration and NRH can be combined for prodromal assessment and/or monitoring disease progression.
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影响因子：
4.8
作者：
Boeve, B. F.;Silber, M. H.;Ferman, T. J.;Lin, S. C.;Benarroch, E. E.;Schmeichel, A. M.;Ahlskog, J. E.;Caselli, R. J.;Jacobson, S.;Sabbagh, M.;Adler, C.;Woodruff, B.;Beach, T. G.;Iranzo, A.;Gelpi, E.;Santamaria, J.;Tolosa, E.;Singer, C.;Mash, D. C.;Luca, C.;Arnulf, I.;Duyckaerts, C.;Schenck, C. H.;Mahowald, M. W.;Dauvilliers, Y.;Graff-Radford, N. R.;Wszolek, Z. K.;Parisi, J. E.;Dugger, B.;Murray, M. E.;Dickson, D. W.
通讯作者：
Dickson, D. W.
影响因子：
14.5
作者：
Postuma, Ronald B.;Iranzo, Alex;Pelletier, Amelie
通讯作者：
Pelletier, Amelie
影响因子：
9.9
作者：
Montplaisir, J;Petit, D;Gauthier, S
通讯作者：
Gauthier, S
影响因子：
16.2
作者：
Tononi G;Cirelli C
通讯作者：
Cirelli C
DOI：
10.1177/0271678x20982388
发表时间：
2021-09
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
Kylkilahti TM;Berends E;Ramos M;Shanbhag NC;Töger J;Markenroth Bloch K;Lundgaard I
通讯作者：
Lundgaard I