Endogenous oestrogens predict 4-year decline in verbal fluency in postmenopausal women: the Rancho Bernardo Study.
Endogenous oestrogens predict 4-year decline in verbal fluency in postmenopausal women: the Rancho Bernardo Study.
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DOI：
10.1111/j.1365-2265.2009.03599.x
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发表时间：
2010-01
影响因子：
3.2
通讯作者：
Barrett-Connor E
中科院分区：
文献类型：
--
作者：
Laughlin GA;Kritz-Silverstein D;Barrett-Connor E
尽管具有压倒性的生物学可接受性，雌激素对绝经后妇女认知功能保护作用的证据并不一致。本研究探讨了内源性雌激素水平和随后的四年下降的认知功能测试性能在社区居住的老年妇女之间的关联。纵向队列研究343绝经后妇女（中位年龄70岁）在1984年和1987年之间，血清中的性激素测量沿着相关的协变量。认知功能在1988-91年和1992-96年再次使用类别流畅性测试、简易精神状态检查（MMSE）和连线测试B（Trails B）进行评估。雌酮和生物可利用雌二醇水平最高的三分位数的妇女，与年龄和教育程度最低的三分位数的妇女相比，类别流畅性（额叶功能测试）4年下降的几率分别高1.75（95%CI 1.02，3.07）和1.79（95%CI 1.04，3.10）。雌酮和生物可利用雌二醇水平最高三分位数的20%女性的语言流畅性丧失几率高两倍（OR=2.17; 95%CI 1.21，3.89），调整睾酮水平或与高内源性雌激素相关的肥胖相关因素（较高的BMI、腰围和甘油三酯，以及较低的HDL胆固醇）并没有改变结果。雌激素与MMSE或Trails B评分的变化无关。绝经后妇女内源性雌激素水平升高与语言流畅性下降相关。这种关联不能用雄激素升高或肥胖或肥胖相关因素来解释。
Despite overwhelming biological plausibility, evidence for a protective effect of estrogen on cognitive function in postmenopausal women is inconsistent. This study examines the association between endogenous estrogen levels and subsequent four-year decline in cognitive function test performance in community-dwelling older women. Longitudinal cohort study 343 postmenopausal women (median age 70 yrs) Between 1984 and 1987, serum for measurement of sex hormones was obtained along with relevant covariates. Cognitive function was assessed in 1988–91 and again in 1992–96 using the Category Fluency test, the Mini-Mental Status Exam (MMSE) and Trail Making Test B (Trails B). Women in the highest tertile of estrone and bioavailable estradiol had, respectively, 1.75 (95% CI 1.02, 3.07) and 1.79 (95% CI 1.04, 3.10) higher odds of 4 year decline in Category Fluency, a test of frontal lobe function, compared to those in the lowest tertile, independent of age and education. The 20% of women with highest tertile levels of both estrone and bioavailable estradiol had a two-fold higher odds of verbal fluency loss (OR=2.17; 95% CI 1.21, 3.89) Adjustment for testosterone levels or for obesity-related factors associated with high endogenous estrogens (higher BMI, waist girth, and triglycerides, and lower HDL cholesterol) did not alter results. Neither estrogen was associated with change in MMSE or Trails B scores. Higher endogenous estrogen levels were associated with greater decline in verbal fluency in postmenopausal women. This association was not explained by elevated androgens or by obesity or obesity-related factors.
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DOI：
10.1097/00001648-199001000-00010
发表时间：
1990-01-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Rothman, K J
通讯作者：
Rothman, K J
影响因子：
--
作者：
den Heijer, T;Geerlings, MI;Breteler, MMB
通讯作者：
Breteler, MMB
影响因子：
5.9
作者：
Grady, D;Yaffe, K;Barrett-Connor, E
通讯作者：
Barrett-Connor, E
影响因子：
3.7
作者：
Keenan, PA;Ezzat, WH;Moore, GJ
通讯作者：
Moore, GJ
影响因子：
5
作者：
CAULEY, JA;GUTAI, JP;POWELL, JG
通讯作者：
POWELL, JG