Engineering bacterial membrane nanovesicles for improved therapies in infectious diseases and cancer.
Engineering bacterial membrane nanovesicles for improved therapies in infectious diseases and cancer.
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工程化细菌膜纳米囊泡用于改善传染病和癌症的治疗。
DOI：
10.1016/j.addr.2022.114340
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发表时间：
2022-07
影响因子：
16.1
通讯作者：
中科院分区：
文献类型：
--
作者：
细菌膜囊泡（BMV）的研究是一个新兴的课题，其目标是解决BMV是否可以带来翻译工具，以改善目前的治疗。本文综述了近年来BMV的研究进展，包括BMV的生产、BMV的种类以及BMV在感染性疾病和癌症治疗中的应用。我们描述了几种BMV的平台，如外膜囊泡（OMV），内膜囊泡（IMV）和双膜囊泡（DMV），这些结构产生于革兰氏阴性或革兰氏阳性细菌。我们还讨论了如何使用化学，物理和遗传方法设计和制定新的和新颖的BMV。在治疗方面，我们分析了目前在BMV中装载药物的方法，并讨论了它们的局限性。最后，我们回顾了几种BMV治疗平台，这些平台已被用于改善感染性疾病和癌症的治疗。尽管BMV提供了有前途的生物医学应用，但需要开发严格的途径和方法来产生可重复和可扩展的药物递送系统用于翻译。
Research on bacterial membrane vesicles (BMVs) is an emerging topic, and the goal is to address whether BMVs can bring translational tools to improve current therapies. In this review, we provided the updated studies on BMVs including their production, their types, and therapeutic regimens for treating infectious diseases and cancers. We described several platforms of BMVs, such as outer membrane vesicles (OMVs), inner membrane vesicles (IMVs) and double membrane vesicles (DMVs), and those structures were produced from Gram-negative or Gram-positive bacteria. We also discussed how to engineer and formulate new and novel BMVs using chemical, physical, and genetic methods. For therapies, we analyzed current methods for loading drugs in BMVs and discussed their limitations. Finally, we reviewed several therapeutic platforms of BMVs that have been exploited in improving the treatments of infectious diseases and cancers. Although BMVs offer the promising biomedical applications, it is needed to develop rigorous approaches and methods to generate reproducible and scalable drug delivery systems for translation.
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DOI：
10.1038/nrmicro3480
发表时间：
2015-10
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Brown L;Wolf JM;Prados-Rosales R;Casadevall A
通讯作者：
Casadevall A
影响因子：
3.7
作者：
Aly, Rasha G. O.;El-Enbaawy, Mona I. H.;Ata, Nagwa S.
通讯作者：
Ata, Nagwa S.
影响因子：
4.2
作者：
Alves, Nathan J.;Turner, Kendrick B.;Walper, Scott A.
通讯作者：
Walper, Scott A.
DOI：
10.1073/pnas.1403683111
发表时间：
2014-04-15
影响因子：
11.1
作者：
Altindis, Emrah;Fu, Yang;Mekalanos, John J.
通讯作者：
Mekalanos, John J.
影响因子：
1.4
作者：
Badamchi, Ali;Bahrami, Fariborz;Siadat, Seyed Davar
通讯作者：
Siadat, Seyed Davar