Circadian Regulation of Hippocampal-Dependent Memory: Circuits, Synapses, and Molecular Mechanisms.
Circadian Regulation of Hippocampal-Dependent Memory: Circuits, Synapses, and Molecular Mechanisms.
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DOI：
10.1155/2018/7292540
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发表时间：
2018
影响因子：
3.1
通讯作者：
Obrietan K
中科院分区：
文献类型：
--
作者：
Snider KH;Sullivan KA;Obrietan K
学习和记忆效率的昼夜节律调节是一种进化上保守的现象，发生在从无脊椎动物到高等哺乳动物物种（包括人类）的生物体中。虽然下丘脑的视交叉上核（SCN）作为哺乳动物的主起搏器，最近的证据表明，前脑区域，包括海马，表现出振荡能力。这一发现，以及对学习和记忆基础的细胞信号事件的研究，为研究精确的细胞，分子和基于电路的机制开辟了有希望的新途径，通过这些机制，时钟计时影响可塑性和认知。在这篇综述中，我们研究了时钟定时和记忆之间的复杂分子关系，重点是依赖于大脑的任务。我们评估了在SCN水平和辅助前脑时钟水平上，昼夜节律定时失调如何影响学习和记忆。此外，我们讨论了实验验证的细胞内信号传导途径（例如，ERK/MAPK和GSK 3 β）以及生物钟影响学习和记忆形成的潜在细胞信号传导机制。最后，我们研究如何长时程增强（LTP），突触过程的几种形式的记忆的建立至关重要，是由时钟门控过程。
Circadian modulation of learning and memory efficiency is an evolutionarily conserved phenomenon, occurring in organisms ranging from invertebrates to higher mammalian species, including humans. While the suprachiasmatic nucleus (SCN) of the hypothalamus functions as the master mammalian pacemaker, recent evidence suggests that forebrain regions, including the hippocampus, exhibit oscillatory capacity. This finding, as well as work on the cellular signaling events that underlie learning and memory, has opened promising new avenues of investigation into the precise cellular, molecular, and circuit-based mechanisms by which clock timing impacts plasticity and cognition. In this review, we examine the complex molecular relationship between clock timing and memory, with a focus on hippocampal-dependent tasks. We evaluate how the dysregulation of circadian timing, both at the level of the SCN and at the level of ancillary forebrain clocks, affects learning and memory. Further, we discuss experimentally validated intracellular signaling pathways (e.g., ERK/MAPK and GSK3β) and potential cellular signaling mechanisms by which the clock affects learning and memory formation. Finally, we examine how long-term potentiation (LTP), a synaptic process critical to the establishment of several forms of memory, is regulated by clock-gated processes.
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影响因子：
3.2
作者：
Belle MD
通讯作者：
Belle MD
影响因子：
2.8
作者：
Cermakian N;Lange T;Golombek D;Sarkar D;Nakao A;Shibata S;Mazzoccoli G
通讯作者：
Mazzoccoli G
影响因子：
3.4
作者：
Antle, Michael C.;Tse, Floria;Hagel, Kimberly
通讯作者：
Hagel, Kimberly
DOI：
10.1073/pnas.1014523107
发表时间：
2010-11-02
影响因子：
11.1
作者：
Andrews, Jessica L.;Zhang, Xiping;Esser, Karyn A.
通讯作者：
Esser, Karyn A.
影响因子：
3.8
作者：
Boden, Michael J.;Varcoe, Tamara J.;Kennaway, David J.
通讯作者：
Kennaway, David J.