The relationship between the rate of transposition and transposable element copy number for copia and Doc retrotransposons of Drosophila melanogaster.
The relationship between the rate of transposition and transposable element copy number for copia and Doc retrotransposons of Drosophila melanogaster.
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果蝇copia和Doc逆转录转座子的转座率与转座元件拷贝数之间的关系。
DOI：
10.1017/s0016672398003358
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Filatov,DA
中科院分区：
文献类型：
--
作者：
Pasyukova,EG;Nuzhdin,SV;Filatov,DA
我们目前的数据之间的关系，转座率和拷贝数的基因组中的copia和文件反转录转座子的果蝇。分别使用个体雄性或雌性在等基因2b系的亚系中直接测量copia和Doc转座率，每个基因组copia拷贝数的范围为49至103，Doc拷贝数的范围为112至235。copia的转座率为3×10−4 ~ 2×10−2，Doc的转座率为2×10−4 ~ 2×10−3。当对所有2b个体的数据进行分析时，发现copia和Doc的转座率和拷贝数之间存在正相关关系;当对两种反转录转座子的亚系平均值进行分析时，未发现显著相关性。总的来说，copia和Doc转座率与它们在基因组中的拷贝数之间的相关性（如果有的话）不是负的，如果转座因子（TE）自我调节它们的拷贝数，这是可以预期的。因此，对于copia和Doc，没有提供自我调节的证据，并且至少对于这两个TE，该假设不适于解释自然群体特有的稳定拷贝数的维持。copia的转座率被测量了两次，在1994年发现了拷贝数和转座率之间的强正相关，而在1995年没有发现相关性，这一事实与转座率和TE拷贝数之间的正相关可能是未来宿主-TE协同进化的默认起点的假设是一致的。
We present data on the relationship between the rate of transposition and copy number in the genome for the copia and Doc retrotransposons of Drosophila melanogaster. copia and Doc transposition rates were directly measured in sublines of the isogenic 2b line using individual males or females, respectively, with a range of copia copy numbers from 49 to 103 and Doc copy numbers from 112 to 235 per genome. Transposition rates varied from 3×10−4 to 2×10−2 for copia and from 2×10−4 to 2×10−3 for Doc. A positive relationship between transposition rate and copy number was found both for copia and for Doc when the data were analysed across all the 2b individuals; no significant correlation was found when the data were analysed across the subline means for both retrotransposons tested. Overall, correlation between copia and Doc transposition rate and their copy number in the genome, if any, was not negative, which would be expected if transposable elements (TEs) self-regulate their copy number. Thus, for copia and Doc no evidence for self-regulation was provided, and at least for these two TEs this hypothesis is not favoured for explaining the maintenance of the stable copy number that is characteristic for natural populations. The transposition rate of copia was measured twice, and a strong positive correlation between copy number and transposition rate both across individuals and subline means was found in 1994, while in 1995 no correlation was found. This fact is in agreement with the hypothesis that a positive correlation between the rate of transposition and TE copy number may be a default starting point for future host–TE coevolution.
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