Cardioviral poly(C) tracts and viral pathogenesis.
Cardioviral poly(C) tracts and viral pathogenesis.
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心脏病毒聚（C）束和病毒发病机制。
DOI：
10.1007/978-3-7091-9326-6_8
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Osorio,JE
中科院分区：
文献类型：
--
作者：
Palmenberg,AC;Osorio,JE
Mengovirus is a prototypical member of the cardiovirus genus of the familyPicornaviridae. The positive-strand RNA genome is 7761 bases in length and encodes a polyprotein of 2293 amino acids. The 5′ non-coding region (758 bases) contains an unusual homopolymeric poly(C) tract, which in the wild-type virus, has a sequence of C50UC10. We have discovered through genetic engineering that truncation or deletion of this poly(C) sequence yields infectious virus isolates that grow well in cell culture, but are 106to 109fold less pathogenic to mice than the wild type strain. Animals receiving sublethal doses of the short poly(C) strains characteristically develop high levels of neutralizing antibodies and acquire lifelong protective immunity against challenge with wild type virus. Effectively, the genetically engineered strains are superb vaccines against cardio virus disease. Moreover, their potential is not limited to murine hosts. Pigs and sub-human primates have also been protectively vaccinated with short poly(C) tract Mengo viruses. The molecular mechanism of poly(C)-mediated pathogenesis is currently under study. Most hypotheses link the activity to induction of the antiviral cytokine, interferon.
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孟戈病毒的干扰素敏感突变体。
影响因子：
3.7
作者：
E. H. Simon;S. Kung;T. Koh;P. Brandman
通讯作者：
P. Brandman
影响因子：
64.8
作者：
BROWN, F;NEWMAN, J;FELLNER, P
通讯作者：
FELLNER, P
DOI：
10.1073/pnas.82.3.732
发表时间：
1985-01-01
影响因子：
11.1
作者：
CALLAHAN, PL;MIZUTANI, S;COLONNO, RJ
通讯作者：
COLONNO, RJ
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DOI：
10.1093/clinids/9.5.917
发表时间：
1987
期刊：
Reviews of infectious diseases
影响因子：
--
作者：
G. Jordan;S. Cohen
通讯作者：
S. Cohen
干扰素和聚（I）：聚（C）对不同小鼠品系脑心肌炎病毒糖尿病变体发病机制的影响。
DOI：
10.1089/jir.1988.8.745
发表时间：
1988
期刊：
Journal of interferon research
影响因子：
--
作者：
D. Giron;H. Agostini;D. C. Thomas
通讯作者：
D. C. Thomas