Environment and Lifestyle: Their Influence on the Risk of RA.
Environment and Lifestyle: Their Influence on the Risk of RA.
复制标题
DOI：
10.3390/jcm9103109
复制
发表时间：
2020-09-26
影响因子：
3.9
通讯作者：
Seror R
中科院分区：
文献类型：
--
作者：
Salliot C;Nguyen Y;Boutron-Ruault MC;Seror R
背景资料：风湿性关节炎（RA）是一种复杂的疾病，其中环境因素被认为与遗传因素相互作用，导致触发自身免疫。方法：我们回顾了环境、激素和饮食因素，这些因素被认为与类风湿关节炎的风险有关。结果：吸烟是与类风湿关节炎风险相关性最强的因素，具有明显的基因-环境交互作用。在其他吸入剂中，二氧化硅可能会增加男性患RA的风险。杀虫剂、污染和其他职业吸入剂的证据较少。关于女性激素暴露，有一些流行病学证据表明激素因素与RA风险之间存在联系，尽管文献中并不一致。关于饮食因素，现有的证据是相互矛盾的。大量饮用咖啡似乎与类风湿关节炎风险增加有关，而适量饮酒与类风湿关节炎风险呈负相关，关于其他食物组的证据较少。饮食模式分析（地中海饮食，饮食的炎症潜力或饮食质量）表明，饮食调整对RA高危人群有潜在益处。结论：到目前为止，吸烟和二氧化硅暴露已被重复证明触发RA的出现。然而，许多其他的环境因素进行了研究，主要是病例对照设计。结果是相互矛盾的，研究很少考虑潜在的基因-环境相互作用。有必要进行大规模的前瞻性研究和对易感个体的研究，以更好地了解和预防疾病及其病程。
Background: Rheumatoid arthritis (RA) is a complex disease in which environmental agents are thought to interact with genetic factors that lead to triggering of autoimmunity. Methods: We reviewed environmental, hormonal, and dietary factors that have been suggested to be associated with the risk of RA. Results: Smoking is the most robust factor associated with the risk of RA, with a clear gene–environment interaction. Among other inhalants, silica may increase the risk of RA in men. There is less evidence for pesticides, pollution, and other occupational inhalants. Regarding female hormonal exposures, there is some epidemiological evidence, although not consistent in the literature, to suggest a link between hormonal factors and the risk of RA. Regarding dietary factors, available evidence is conflicting. A high consumption of coffee seems to be associated with an increased risk of RA, whereas a moderate consumption of alcohol is inversely associated with the risk of RA, and there is less evidence regarding other food groups. Dietary pattern analyses (Mediterranean diet, the inflammatory potential of the diet, or diet quality) suggested a potential benefit of dietary modifications for individuals at high risk of RA. Conclusion: To date, smoking and silica exposure have been reproducibly demonstrated to trigger the emergence of RA. However, many other environmental factors have been studied, mostly with a case-control design. Results were conflicting and studies rarely considered potential gene–environment interactions. There is a need for large scale prospective studies and studies in predisposed individuals to better understand and prevent the disease and its course.
登录
查看更多内容
影响因子：
--
作者：
Crowson, Cynthia S.;Matteson, Eric L.;Myasoedova, Elena;Michet, Clement J.;Ernste, Floranne C.;Warrington, Kenneth J.;Davis, John M., III;Hunder, Gene G.;Therneau, Terry M.;Gabriel, Sherine E.
通讯作者：
Gabriel, Sherine E.
影响因子：
4.9
作者：
Benito-Garcia E;Feskanich D;Hu FB;Mandl LA;Karlson EW
通讯作者：
Karlson EW
影响因子：
2.5
作者：
Chen, Qi;Jin, Zhichao;He, Jia
通讯作者：
He, Jia
影响因子：
4.9
作者：
Di Giuseppe D;Discacciati A;Orsini N;Wolk A
通讯作者：
Wolk A
影响因子：
10.4
作者：
De Roos AJ;Koehoorn M;Tamburic L;Davies HW;Brauer M
通讯作者：
Brauer M