Clinical Relevance of Helicobacter pylori Infection.
Clinical Relevance of Helicobacter pylori Infection.
复制标题
幽门螺杆菌感染的临床相关性。
DOI：
10.3390/jcm10163473
复制
发表时间：
2021-08-06
影响因子：
3.9
通讯作者：
Mladenova I
中科院分区：
文献类型：
--
作者：
Mladenova I
幽门螺杆菌 (H. pylori) 是一种革兰氏阴性螺旋状微需氧细菌，定植于胃窦和胃体，通过抗酸和定植因子机制在恶劣的环境中生存。它感染了世界上大约 50% 的人口。尽管这种感染的流行率因国家、不同种族、社会或年龄组而异，但估计约 50% 的人口仅携带这种微生物。虽然已发现幽门螺杆菌在慢性胃炎、消化性溃疡病和胃癌中发挥重要的病因和致病作用，但其对于多种类型的胃外疾病的重要性仍需进一步研究。诊断幽门螺杆菌感染（定义为侵入性或非侵入性）的测试选择取决于是否进行上消化道内窥镜检查的临床指征。以根除细菌为重点，应根据抗生素的使用情况和记录的抗生素耐药性在当地决定治疗方案。作者概述了幽门螺杆菌感染临床方面的知识现状，特别是其诊断和治疗管理。
Helicobacter pylori (H. pylori) is a Gram-negative helical, microaerophilic bacterium which colonizes the antrum and body of the stomach, surviving in its harsh environment through mechanisms of acid resistance and colonization factors. It infects approximately 50% of the world population. Although the prevalence of this infection varies from country to country, as well as between different ethnic, social or age groups, it is estimated that about 50% of the human population only carries this microorganism. While H. pylori has been found to play a major etiological and pathogenic role in chronic gastritis, peptic ulcer disease and gastric cancer, its importance for many types of extra-gastric disease needs to be further investigated. The choice of tests to diagnose H. pylori infection, defined as invasive or non-invasive, depends on the clinical indication as to whether to perform upper gastrointestinal endoscopy. Focusing on bacterial eradication, the treatment should be decided locally based on the use of antibiotics and documented antibiotic resistance. The author provides an overview of the current state of knowledge about the clinical aspects of H. pylori infection, especially its diagnostic and therapeutic management.
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DOI：
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发表时间：
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影响因子：
--
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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期刊：
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影响因子：
--
作者：
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影响因子：
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