The papez circuit in first-episode, treatment-naive adults with major depressive disorder: combined atlas-based tract-specific quantification analysis and voxel-based analysis.
The papez circuit in first-episode, treatment-naive adults with major depressive disorder: combined atlas-based tract-specific quantification analysis and voxel-based analysis.
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DOI：
10.1371/journal.pone.0126673
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Wang F
中科院分区：
文献类型：
--
作者：
Jiang W;Gong G;Wu F;Kong L;Chen K;Cui W;Ren L;Fan G;Sun W;Ma H;Xu K;Tang Y;Wang F
先前的研究结果表明，帕佩兹回路可能在重度抑郁症中起作用。我们使用基于图谱的束特异性定量分析和基于体素的分析来检查参与情绪调节的白质束的完整性（包括Papez回路中的束）。对35例首发、未接受治疗的重度抑郁症成人和34例健康成人对照进行弥散张量成像比较。我们的统计方法比较了11个主要白质束在重度抑郁症患者和成人对照组之间的结构完整性，以及病程对患者的影响。根据两种分析方法，海马扣带和丘脑前辐射的部分各向异性降低，所有这些都是Papez回路中的重要束。我们的研究结果支持Papez回路在重度抑郁症中的作用，由于两种分析结果相似，具有互补的优势，因此假阳性的可能性很小。Papez回路功能障碍可能是研究重度抑郁症发病机制的一个潜在标志。
Previous findings suggest that the Papez Circuit may have a role in major depressive disorders. We used atlas-based tract-specific quantification analysis and voxel-based analysis to examine the integrity of white matter tracts involved in mood regulation (including tracts in the Papez Circuit). Diffusion tensor imaging acquired from 35 first-episode, treatment-naive adults with major depressive disorders and 34 healthy adult controls were compared. Our statistical approach compared structural integrity of 11 major white matter tracts between the major depressive disorder and adult controls, as well as illness duration influence in patients. Fractional anisotropy was decreased in the hippocampal cingulum and in the anterior thalamic radiation according to both analytical approaches, all of which were important tracts included in the Papez Circuit. Our results support the role of the Papez Circuit in major depressive disorders with the minimal probability of false positive due to similar findings in both analyses that have complementary advantages. Dysfunction of the Papez Circuit may be a potential marker for studying the pathogenesis of major depressive disorders.
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影响因子：
4.8
作者：
Kong, Lingtao;Chen, Kaiyuan;Womer, Fay;Jiang, Wenyan;Luo, Xingguang;Driesen, Naomi;Liu, Jie;Blumberg, Hilary;Tang, Yanqing;Xu, Ke;Wang, Fei
通讯作者：
Wang, Fei
影响因子：
3.7
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通讯作者：
Hoptman, Matthew J.
DOI：
10.1016/j.jaac.2009.11.005
发表时间：
2010-02-01
影响因子：
13.3
作者：
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通讯作者：
Lim, Kelvin O.
影响因子：
2.3
作者：
Dalby, Rikke Beese;Frandsen, Jesper;Ostergaard, Leif
通讯作者：
Ostergaard, Leif