Insights into the characteristics of mammalian cardiomyocyte terminal differentiation shown through the study of mice with a dysfunctional c-kit.
Insights into the characteristics of mammalian cardiomyocyte terminal differentiation shown through the study of mice with a dysfunctional c-kit.
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DOI：
10.1007/s00246-008-9366-1
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发表时间：
2009-07
影响因子：
1.6
通讯作者：
Husain, Ahsan
中科院分区：
文献类型：
--
作者：
Naqvi, Nawazish;Li, Ming;Yahiro, Eiji;Graham, Robert M.;Husain, Ahsan
哺乳动物心肌细胞在出生后不久就退出细胞周期。这个过程称为终末分化。 c-kit 是一种受体酪氨酸激酶，出生后立即在心肌细胞上表达，但仅持续几天。在具有遗传性 c-kit 功能障碍的小鼠中，成年心肌细胞在表型上与野生型小鼠的心肌细胞没有区别，只是它们能够在急性压力超负荷后在体内增殖。本综述探讨了这样的观点，即出生后心肌细胞分化和细胞周期退出是不同的过程，并且终末分化可能不仅仅是由于调节细胞周期的基因表达改变所致，还可能涉及 c-kit 诱导的表观遗传变化。
Mammalian cardiomyocytes withdraw from the cell cycle soon after birth. This process is called terminal differentiation. The c-kit, a receptor tyrosine kinase, is expressed on cardiomyocytes immediately after birth but for only a few days. In mice with genetic c-kit dysfunction, adult cardiomyocytes are phenotypically indistinguishable from those of wild type mice, except that they are capable of proliferation in vivo after acute pressure overload. This review explores the idea that postnatal cardiomyocyte differentiation and cell cycle withdrawal are distinct processes and that terminal differentiation may not simply be due to altered expression of genes that regulate the cell cycle but could involve c-kit induced epigenetic change.
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