Layered double hydroxide-hemin nanocomposite as mimetic peroxidase and its application in sensing
Layered double hydroxide-hemin nanocomposite as mimetic peroxidase and its application in sensing
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层状双氢氧化物-血红素纳米复合物作为模拟过氧化物酶及其在传感中的应用
DOI：
10.1016/j.snb.2013.10.097
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发表时间：
2014-03
影响因子：
8.4
通讯作者：
Zhang, Xin-Xiang
中科院分区：
文献类型：
--
作者：
Zhou, Ying-Lin;Ma, Yu-Rong;Qi, Li-Min;Zhang, Xin-Xiang
以水热法制备的铁镍LDH纳米片为载体，将hemin固定在两者之间，制备了一种新型的模拟过氧化物酶——层状双氢氧化物(LDH)-hemin纳米复合材料。通过紫外-可见光谱和电化学测量证实，与血红素相比，其对h2o2的过氧化物酶样活性有所提高。基于Fe-Ni LDH-hemin纳米复合材料的电化学传感器对h2o2的响应速度快，线性范围为1 ~ 240 μM，基于3的信噪比和高选择性，检测限为0.3 μM。其性能优于相同条件下制备的HRP和血红蛋白传感器。该传感器的高性能使ldh -血红蛋白纳米复合材料成为一种很有前途的模拟过氧化物酶，可以取代天然酶。
A novel mimetic peroxidase, layered double hydroxide (LDH)-hemin nanocomposite, was first prepared by immobilizing hemin between the nanosheets of Fe–Ni LDH obtained through hydrothermal method. It showed an improved peroxidase-like activity to H2O2compared with hemin alone, which was proved by UV–Vis spectroscopy and electrochemical measurements. The electrochemical sensor based on Fe–Ni LDH-hemin nanocomposite exhibited a fast response to H2O2with good linear range of 1–240 μM, a detection limit of 0.3 μM based on a signal-to-noise ratio of 3 and high selectivity. It performed better than the sensors based on HRP and hemin which were prepared in the same conditions. The high performance of the sensor made LDH-hemin nanocomposite a promising mimetic peroxidase to replace natural enzymes.
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