Modulation of recognition memory performance by light and its relationship with cortical EEG theta and gamma activities.
Modulation of recognition memory performance by light and its relationship with cortical EEG theta and gamma activities.
复制标题
光对识别记忆的调节及其与皮层脑电theta和gamma活动的关系
DOI：
10.1016/j.bcp.2020.114404
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发表时间：
2021-09
影响因子：
5.8
通讯作者：
Peirson SN
中科院分区：
文献类型：
--
作者：
Hasan S;Tam SKE;Foster RG;Vyazovskiy VV;Bannerman DM;Peirson SN
急性光暴露除了在光携带中起关键作用外，还对生理产生广泛的影响。虽然光对生理唤醒的调节作用在小鼠身上得到了很好的证明，但它对记忆表现的影响并不确定，因为影响的方向取决于所使用的行为任务的性质和/或所使用的刺激的类型。此外，在所有报告光对表现有显著影响的啮齿动物研究中，在任务期间没有对大脑活动进行评估，因此不清楚光是如何调节大脑活动的，也不清楚光调制的脑活动与表现之间的确切关系。在这里，我们使用自发识别记忆任务，研究了不同强度的光对小鼠的识别记忆表现和额顶觉醒脑电(EEG)的调制效应。我们报告了在群体水平上对识别记忆表现的光强度依赖的干扰效应，但对个体水平的数据检查表明，在某些情况下观察到光强度依赖的促进作用。然后，利用线性混合效应模型，我们证明了编码时的脑电快速theta(θ)活动对识别记忆性能有负面预测作用，而提取时的慢伽马(γ)活动对识别记忆性能有正向预测作用。这些θ/γ活性和表现之间的关系随着光照强度的增加而加强。因此，光调制了注意和助记过程中涉及的θ和γ带活动，从而影响识别记忆性能。然而，外部因素，包括内部时钟的相位和稳态睡眠压力，可能决定光输入如何转化为行为表现。
Acute exposure to light exerts widespread effects on physiology, in addition to its key role in photoentrainment. Although the modulatory effect of light on physiological arousal is well demonstrated in mice, its effect on memory performance is inconclusive, as the direction of the effect depends on the nature of the behavioural task employed and/or the type of stimulus utilised. Moreover, in all rodent studies that reported significant effects of light on performance, brain activity was not assessed during the task and thus it is unclear how brain activity was modulated by light or the exact relationship between light-modulated brain activity and performance. Here we examine the modulatory effects of light of varying intensities on recognition memory performance and frontoparietal waking electroencephalography (EEG) in mice using the spontaneous recognition memory task. We report a light-intensity-dependent disruptive effect on recognition memory performance at the group level, but inspection of individual-level data indicates that light-intensity-dependent facilitation is observed in some cases. Using linear mixed-effects models, we then demonstrate that EEG fast theta (θ) activity at the time of encoding negatively predicts recognition memory performance, whereas slow gamma (γ) activity at the time of retrieval positively predicts performance. These relationships between θ/γ activity and performance are strengthened by increasing light intensity. Thus, light modulates θ and γ band activities involved in attentional and mnemonic processes, thereby affecting recognition memory performance. However, extraneous factors including the phase of the internal clock at which light is presented and homeostatic sleep pressure may determine how photic input is translated into behavioural performance.
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影响因子：
2.7
作者：
Dix, SL;Aggleton, JP
通讯作者：
Aggleton, JP
影响因子：
2.7
作者：
ENNACEUR, A;DELACOUR, J
通讯作者：
DELACOUR, J
影响因子：
16.6
作者：
Etter, Guillaume;van der Veldt, Suzanne;Williams, Sylvain
通讯作者：
Williams, Sylvain
DOI：
10.1073/pnas.1320005111
发表时间：
2014-04-22
影响因子：
11.1
作者：
Chellappa, Sarah Laxhmi;Ly, Julien Q. M.;Vandewalle, Gilles
通讯作者：
Vandewalle, Gilles
DOI：
10.1152/ajpregu.1998.275.4.r1127
发表时间：
1998-10-01
影响因子：
2.8
作者：
Franken, P;Malafosse, A;Tafti, M
通讯作者：
Tafti, M