Antifungal activity of Arctotis arctotoides (L.f.) O. Hoffm. and Gasteria bicolor Haw. against opportunistic fungi associated with human immunodeficiency virus/acquired immunodeficiency syndrome.
Antifungal activity of Arctotis arctotoides (L.f.) O. Hoffm. and Gasteria bicolor Haw. against opportunistic fungi associated with human immunodeficiency virus/acquired immunodeficiency syndrome.
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DOI：
10.4103/0973-1296.96564
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发表时间：
2012-04
影响因子：
0.7
通讯作者：
Ndip RN
中科院分区：
文献类型：
--
作者：
Otang WM;Grierson DS;Ndip RN
在南非，由于艾滋病大流行，许多患者免疫功能低下，机会性真菌感染，如主要由白色念珠菌引起的念珠菌病很常见。牛蒡子和二色天麻是传统医学中治疗艾滋病的常用植物。本研究的目的是研究A. arctotoides和G.双色对机会性真菌常见的艾滋病毒/艾滋病患者。采用琼脂扩散法和微量稀释法测定药用植物提取物对10种条件致病真菌的抑菌活性。所有的己烷和丙酮提取物对至少一种真菌具有活性，抑制区从8到32 mm不等，而水提取物对任何真菌都没有活性。活性提取物的抑制活性，基于总的平均抑制直径，按顺序为：A. arctotoides（己烷）> A. arctotoides（丙酮）> G. bicolor（己烷）> G.双色（丙酮）。最敏感的真菌，基于生长抑制的总体平均直径，是光滑念珠菌，C。krusei和犬小孢子菌，而新生隐球菌、断端锥癣菌和石膏样小孢子菌对任何提取物都不敏感，即使在使用的最高浓度为5 mg/ml时也是如此。这项研究验证了这些植物在传统医学中用于治疗艾滋病毒/艾滋病患者继发性真菌感染的用途。
In South Africa where many patients are immunocompromised as a result of the AIDS pandemic, opportunistic fungal infections such as candidiasis caused mainly by Candida albicans are common. Arctotis arctotoides and Gasteria bicolor are two plants which are frequently and commonly used in traditional medicine in the treatment of HIV patients. The aim of this study was to investigate the antifungal activity of A. arctotoides and G. bicolor against opportunistic fungi common in HIV/AIDS patients. The agar diffusion and micro-dilution methods were used to determine the antifungal activities of the medicinal plant extracts against 10 opportunistic fungi. All the hexane and acetone extracts were active against at least one of the fungi with zones of inhibition varying from 8 to 32 mm, while none of the aqueous extracts was active against any of the fungi. The inhibitory activity of the active extracts, based on the overall mean inhibition diameters, was in the order: A. arctotoides (hexane) > A. arctotoides (acetone) > G. bicolor (hexane) > G. bicolor (acetone). The most susceptible fungi, based on the overall mean diameter of growth inhibition, were Candida glabrata, C. krusei, and Microsporum canis, while Cyptococcus neoformans, Trycophyton tonsurans, and Microsporum gypseum were not susceptible to any of the extracts even at 5 mg/ml which was the highest concentration used. This study validates the use of these plants in traditional medicine in the treatment of secondary fungal infections in HIV/AIDS patients.
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影响因子：
3.1
作者：
Sultana, N;Afolayan, AJ
通讯作者：
Afolayan, AJ
影响因子：
5.4
作者：
Jones, NP;Arnason, JT;Smith, ML
通讯作者：
Smith, ML
影响因子：
5.4
作者：
Duarte, MCT;Figueira, GM;Delarmelina, C
通讯作者：
Delarmelina, C
影响因子：
3.5
作者：
Kelly, SL;Lamb, DC;Einsele, H
通讯作者：
Einsele, H
影响因子：
5.4
作者：
Hamza, Omar J. M.;den Beukel, Carolien J. P. van den Bout-van;Verweij, Paul E.
通讯作者：
Verweij, Paul E.