Variant Analysis of SARS-CoV-2 Genomes from Belgian Military Personnel Engaged in Overseas Missions and Operations.
Variant Analysis of SARS-CoV-2 Genomes from Belgian Military Personnel Engaged in Overseas Missions and Operations.
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DOI：
10.3390/v13071359
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发表时间：
2021-07-13
期刊：
影响因子：
--
通讯作者：
Baele G
中科院分区：
文献类型：
--
作者：
Pirnay JP;Selhorst P;Hong SL;Cochez C;Potter B;Maes P;Petrillo M;Dudas G;Claes V;Van der Beken Y;Verbeken G;Degueldre J;Dellicour S;Cuypers L;T'Sas F;Van den Eede G;Verhasselt B;Weuts W;Smets C;Mertens J;Geeraerts P;Ariën KK;André E;Neirinckx P;Soentjens P;Baele G
在首次鉴定出严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 作为中国 2019 年冠状病毒病 (COVID-19) 的病原体一年多后，该病毒基因组变体通过旅行的出现和传播引起了人们对在以前未受影响的地区引入谱系的担忧，需要采取适当的遏制策略。与此同时，此类引入加剧了人们对传播性和疾病严重程度可能增加以及疫苗功效可能下降的担忧。军事人员经常被部署到世界各地执行任务。作为 COVID-19 风险缓解策略的一部分，在执行任务前和任务后，对参与海外任务和行动的比利时武装部队进行了筛查（7683 次 RT-qPCR 检测），以确定是否存在 SARS-CoV-2，包括识别病毒谱系。在从尼日尔、刚果民主共和国、阿富汗和马里执行任务返回的士兵中发现了九种不同的病毒基因型。 SARS-CoV-2变体属于主要分支19B、20A和20B（Nextstrain命名法），包括“感兴趣的变体”B.1.525、“监测下的变体”A.27，以及谱系B.1.214、B.1、B.1.1.254和A（穿山甲命名法），其中一些由于特定的突变而受到国际监测他们港口。通过接触者追踪和系统发育分析，我们表明比利时军事指挥部实施的隔离和检测政策似乎成功地遏制了这些不同的 SARS-CoV-2 变种向军队和平民的流入和传播。
More than a year after the first identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the causative agent of the 2019 coronavirus disease (COVID-19) in China, the emergence and spread of genomic variants of this virus through travel raise concerns regarding the introduction of lineages in previously unaffected regions, requiring adequate containment strategies. Concomitantly, such introductions fuel worries about a possible increase in transmissibility and disease severity, as well as a possible decrease in vaccine efficacy. Military personnel are frequently deployed on missions around the world. As part of a COVID-19 risk mitigation strategy, Belgian Armed Forces that engaged in missions and operations abroad were screened (7683 RT-qPCR tests), pre- and post-mission, for the presence of SARS-CoV-2, including the identification of viral lineages. Nine distinct viral genotypes were identified in soldiers returning from operations in Niger, the Democratic Republic of the Congo, Afghanistan, and Mali. The SARS-CoV-2 variants belonged to major clades 19B, 20A, and 20B (Nextstrain nomenclature), and included “variant of interest” B.1.525, “variant under monitoring” A.27, as well as lineages B.1.214, B.1, B.1.1.254, and A (pangolin nomenclature), some of which are internationally monitored due to the specific mutations they harbor. Through contact tracing and phylogenetic analysis, we show that isolation and testing policies implemented by the Belgian military command appear to have been successful in containing the influx and transmission of these distinct SARS-CoV-2 variants into military and civilian populations.
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DOI：
10.1073/pnas.89.22.10915
发表时间：
1992-11-15
影响因子：
11.1
作者：
HENIKOFF, S;HENIKOFF, JG
通讯作者：
HENIKOFF, JG
DOI：
10.3390/pathogens10020184
发表时间：
2021-02-09
期刊：
Pathogens (Basel, Switzerland)
影响因子：
--
作者：
Flores-Alanis A;Cruz-Rangel A;Rodríguez-Gómez F;González J;Torres-Guerrero CA;Delgado G;Cravioto A;Morales-Espinosa R
通讯作者：
Morales-Espinosa R
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
10.7
作者：
Katoh K;Standley DM
通讯作者：
Standley DM
影响因子：
3.7
作者：
Laamarti M;Alouane T;Kartti S;Chemao-Elfihri MW;Hakmi M;Essabbar A;Laamarti M;Hlali H;Bendani H;Boumajdi N;Benhrif O;Allam L;El Hafidi N;El Jaoudi R;Allali I;Marchoudi N;Fekkak J;Benrahma H;Nejjari C;Amzazi S;Belyamani L;Ibrahimi A
通讯作者：
Ibrahimi A