Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus.
Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus.
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DOI：
10.1016/j.virol.2012.09.013
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发表时间：
2013-01-20
期刊：
影响因子：
3.7
通讯作者：
Faaberg KS
中科院分区：
文献类型：
--
作者：
Guo B;Lager KM;Henningson JN;Miller LC;Schlink SN;Kappes MA;Kehrli ME Jr;Brockmeier SL;Nicholson TL;Yang HC;Faaberg KS
对美国10周龄猪的2型高致病性猪繁殖与呼吸综合征病毒（HP-PRRSV）的致病性进行了研究。从中国HP-PRRSV感染性克隆中拯救的rJXwn 06在猪中复制，其动力学比美国菌株VR-2332增加至少100倍。与感染VR-2332的猪相比，rJXwn 06在暴露于HP-PRRSV的猪中引起显著的体重减轻、由于细菌性脓毒症引起的疾病加重和更严重的组织病理学肺病变。新的发现包括鉴定存在的细菌种类，观察到的胸腺萎缩程度，以及包括接触动物，这突出了HP-PRRSV在动物之间快速传播的能力。此外，血清，支气管肺泡灌洗液和气管支气管淋巴结组织匀浆的全面详细的细胞因子分析揭示了一个显着的升高与先天性和适应性免疫HP-PRRSV感染的猪细胞因子的水平，并表明，接触猪不同程度的细胞因子反应。
The pathogenesis of Type 2 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) in 10-week old swine in the United States was investigated. rJXwn06, rescued from an infectious clone of Chinese HP-PRRSV, replicated in swine with at least 100-fold increased kinetics over U.S. strain VR-2332. rJXwn06 caused significant weight loss, exacerbated disease due to bacterial sepsis and more severe histopathological lung lesions in pigs exposed to HP-PRRSV than to those infected with VR-2332. Novel findings include identification of bacterial species present, the degree of thymic atrophy seen, and the inclusion of contact animals that highlighted the ability of HP-PRRSV to rapidly transmit between animals. Furthermore, comprehensive detailed cytokine analysis of serum, bronchoalveolar lavage fluid, and tracheobronchial lymph node tissue homogenate revealed a striking elevation in levels of cytokines associated with both innate and adaptive immunity in HP-PRRSV infected swine, and showed that contact swine differed in the degree of cytokine response.
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猪呼吸与繁殖综合征病毒变种，越南和中国，2007 年。
影响因子：
11.8
作者：
Feng Y;Zhao T;Nguyen T;Inui K;Ma Y;Nguyen TH;Nguyen VC;Liu D;Bui QA;To LT;Wang C;Tian K;Gao GF
通讯作者：
Gao GF
影响因子：
5
作者：
Faaberg KS;Kehrli ME Jr;Lager KM;Guo B;Han J
通讯作者：
Han J
影响因子：
1
作者：
Brockmeier, SL;Palmer, MV;Rimler, RB
通讯作者：
Rimler, RB
影响因子：
2.2
作者：
Gomez-Laguna, Jaime;Salguero, Francisco J.;Carrasco, Librado
通讯作者：
Carrasco, Librado
DOI：
10.1089/jir.1989.9.143
发表时间：
1989-02-01
期刊：
JOURNAL OF INTERFERON RESEARCH
影响因子：
--
作者：
ROTH, JA;FRANK, DE
通讯作者：
FRANK, DE