Genomic Analysis of the Multidrug-Resistant Acinetobacter baumannii Strain MDR-ZJ06 Widely Spread in China
Genomic Analysis of the Multidrug-Resistant Acinetobacter baumannii Strain MDR-ZJ06 Widely Spread in China
复制标题
中国广泛传播的多重耐药鲍曼不动杆菌MDR-ZJ06的基因组分析
DOI：
10.1128/aac.01134-10
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发表时间：
2011-07
影响因子：
4.9
通讯作者：
Yu, Yunsong
中科院分区：
文献类型：
--
作者：
Zhou, Hua;Zhang, Tongwu;Yu, Dongliang;Pi, Borui;Yang, Qing;Zhou, Jianying;Hu, Songnian;Yu, Yunsong
摘要我们曾报道多重耐药鲍曼不动杆菌MDR-ZJ 06株在我国广泛流行，属于欧洲克隆II。在这项研究中，我们报告的全基因组序列的临床上重要的菌株。在MDR-ZJ 06中鉴定出一个38.6 kb的AbaR型基因组抗性岛（AbaR 22）。AbaR 22的结构与A.鲍曼不动杆菌AYE和AB 0057的耐药基因较少。在AbaR 22中未发现如前所述的抗性基因积累区域。在菌株MDR-ZJ 06的染色体中，我们鉴定了复合转座子（Tn 2009）中的基因blaoxa-23。Tn 2009与其它A.鲍曼不动杆菌转座子携带blaoxa-23，但它被两个ISAba 1元件包围，这两个元件以相同的方向转录。MDR-ZJ 06也在其质粒pZJ 06上表达阿尔马基因，该基因与肠杆菌科的阿尔马基因具有相同的遗传环境。这些结果表明，即使在密切相关的A。鲍曼不动杆菌。
ABSTRACT We previously reported that the multidrug-resistant (MDR) Acinetobacter baumannii strain MDR-ZJ06, belonging to European clone II, was widely spread in China. In this study, we report the whole-genome sequence of this clinically important strain. A 38.6-kb AbaR-type genomic resistance island (AbaR22) was identified in MDR-ZJ06. AbaR22 has a structure similar to those of the resistance islands found in A. baumannii strains AYE and AB0057, but it contained only a few antibiotic resistance genes. The region of resistant gene accumulation as previously described was not found in AbaR22. In the chromosome of the strain MDR-ZJ06, we identified the gene blaoxa-23 in a composite transposon (Tn2009). Tn2009 shared the backbone with other A. baumannii transponsons that harbor blaoxa-23, but it was bracketed by two ISAba1 elements which were transcribed in the same orientation. MDR-ZJ06 also expressed the armA gene on its plasmid pZJ06, and this gene has the same genetic environment as the armA gene of the Enterobacteriaceae. These results suggest variability of resistance acquisition even in closely related A. baumannii strains.
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影响因子：
3.2
作者：
Mugnier, Pauline D.;Poirel, Laurent;Nordmann, Patrice
通讯作者：
Nordmann, Patrice
影响因子：
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作者：
Post, Virginia;White, Peter A.;Hall, Ruth M.
通讯作者：
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影响因子：
3.2
作者：
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影响因子：
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作者：
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通讯作者：
Ying Zhang;Hua Zhou;Xiaoxiao Shen;P. Shen;Yunsong Yu;Lan-juan Li
影响因子：
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作者：
Lagesen K;Hallin P;Rødland EA;Staerfeldt HH;Rognes T;Ussery DW
通讯作者：
Ussery DW