A literature review and novel theoretical approach on the optical properties of whole blood.
A literature review and novel theoretical approach on the optical properties of whole blood.
复制标题
DOI：
10.1007/s10103-013-1446-7
复制
发表时间：
2014-03
影响因子：
2.1
通讯作者：
Faber, Dirk J.
中科院分区：
文献类型：
--
作者：
Bosschaart, Nienke;Edelman, Gerda J.;Aalders, Maurice C. G.;van Leeuwen, Ton G.;Faber, Dirk J.
关键词：
血液的光学性质测量受到物理和方法学来源的各种因素的影响。这篇综述的目的是列出这些影响因素，并为读者提供可用于生物医学光学实践的全血光学特性光谱（250- 2500 nm）（附录中列出）。为此，我们对文献中血液的光学性质谱进行了严格的检查和选择，从中我们编制了吸收系数（μa）、散射系数（μs）和散射各向异性（g）的平均谱。由此，我们计算约化散射系数（μs′）和有效衰减系数（μeff）。在编制μa和μs时，我们分别考虑了吸收平坦化和相关散射（即红细胞位置之间的空间相关性）的影响。对于依赖散射对μs的影响，我们提出了一个新的，理论推导公式，可用于实际重新缩放μs到其他血细胞比容。由于血液散射特性的测量已被证明是具有挑战性的，我们应用另一种理论方法来计算μs和g的光谱。为此，我们将联合收割机Kramers-Kronig分析与分析散射理论相结合，扩展了Percus-Yevick结构因子，考虑了全血中的依赖散射效应。我们认为，我们计算的光谱可以提供一个更好的估计μs和g（因此μs′和μeff）比编译的光谱从文献中的波长在300和600 nm之间。
Optical property measurements on blood are influenced by a large variety of factors of both physical and methodological origin. The aim of this review is to list these factors of influence and to provide the reader with optical property spectra (250–2,500 nm) for whole blood that can be used in the practice of biomedical optics (tabulated in the appendix). Hereto, we perform a critical examination and selection of the available optical property spectra of blood in literature, from which we compile average spectra for the absorption coefficient (μa), scattering coefficient (μs) and scattering anisotropy (g). From this, we calculate the reduced scattering coefficient (μs′) and the effective attenuation coefficient (μeff). In the compilation of μa and μs, we incorporate the influences of absorption flattening and dependent scattering (i.e. spatial correlations between positions of red blood cells), respectively. For the influence of dependent scattering on μs, we present a novel, theoretically derived formula that can be used for practical rescaling of μs to other haematocrits. Since the measurement of the scattering properties of blood has been proven to be challenging, we apply an alternative, theoretical approach to calculate spectra for μs and g. Hereto, we combine Kramers–Kronig analysis with analytical scattering theory, extended with Percus–Yevick structure factors that take into account the effect of dependent scattering in whole blood. We argue that our calculated spectra may provide a better estimation for μs and g (and hence μs′ and μeff) than the compiled spectra from literature for wavelengths between 300 and 600 nm.
登录
查看更多内容
影响因子：
3.6
作者：
Bosschaart, Nienke;Aalders, Maurice C. G.;van Leeuwen, Ton G.
通讯作者：
van Leeuwen, Ton G.
影响因子：
1.9
作者：
HALE, GM;QUERRY, MR
通讯作者：
QUERRY, MR
影响因子：
1.9
作者：
Friebel, M;Meinke, M
通讯作者：
Meinke, M
影响因子：
3.5
作者：
Friebel, Moritz;Helfmann, Juergen;Meinke, Martina
通讯作者：
Meinke, Martina
影响因子：
3.6
作者：
Finlay, JC;Foster, TH
通讯作者：
Foster, TH