Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells.
Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells.
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DOI：
10.1186/1471-2407-9-414
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发表时间：
2009-11-30
期刊：
影响因子：
3.8
通讯作者：
Koyama H
中科院分区：
文献类型：
--
作者：
Abdulah R;Faried A;Kobayashi K;Yamazaki C;Suradji EW;Ito K;Suzuki K;Murakami M;Kuwano H;Koyama H
西兰花是一种芸苔属蔬菜，被认为具有化学预防特性。硒还显示出作为抗癌剂的前景。因此，西兰花的硒富集具有增强西兰花芽的抗癌特性的潜力。采用亚硒酸钠溶液制备富硒西兰花芽。在人前列腺癌细胞系中评价了它们的抗癌特性，并与对照西兰花芽提取物的抗癌特性进行了比较。富硒青花菜芽在抑制前列腺癌细胞增殖、减少前列腺特异性抗原分泌和诱导前列腺癌细胞凋亡方面均优于普通青花菜芽上级。此外，富硒西兰花芽，而不是正常的西兰花芽，诱导生存Akt/mTOR通路的下调。我们的研究结果表明，富硒西兰花芽可能被用作前列腺癌预防和治疗的替代硒源。
Broccoli is a Brassica vegetable that is believed to possess chemopreventive properties. Selenium also shows promise as an anticancer agent. Thus, selenium enrichment of broccoli has the potential to enhance the anticancer properties of broccoli sprouts. Selenium-enriched broccoli sprouts were prepared using a sodium selenite solution. Their anticancer properties were evaluated in human prostate cancer cell lines and compared with those of a control broccoli sprout extract. Selenium-enriched broccoli sprouts were superior to normal broccoli sprouts in inhibiting cell proliferation, decreasing prostate-specific antigen secretion, and inducing apoptosis of prostate cancer cells. Furthermore, selenium-enriched broccoli sprouts but, not normal broccoli sprouts, induced a downregulation of the survival Akt/mTOR pathway. Our results suggest that selenium-enriched broccoli sprouts could potentially be used as an alternative selenium source for prostate cancer prevention and therapy.
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影响因子：
6.1
作者：
Finley, JW;Ip, C;Whanger, PD
通讯作者：
Whanger, PD
影响因子：
3.9
作者：
Abdulah, Rizky;Koyama, Hiroshi;Murakami, Masami
通讯作者：
Murakami, Masami
影响因子：
3
作者：
Faried, A;Faried, LS;Kuwano, H
通讯作者：
Kuwano, H
DOI：
10.1016/j.jchromb.2005.09.041
发表时间：
2005-12-15
影响因子：
3
作者：
Liang, H;Yuan, QP;Xiao, Q
通讯作者：
Xiao, Q
影响因子：
9.7
作者：
Dinkova-Kostova, Albena T.;Jenkins, Stephanie N.;Talalay, Paul
通讯作者：
Talalay, Paul